GYNE SE2 menopause Flashcards Preview

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Flashcards in GYNE SE2 menopause Deck (22)
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1
Q

absence of menstrual periods for at least 6 months in a woman over 40

A

menopause

2
Q

more rapid oocyte depletion and hypoestrogenism starting age 37

A

perimenopause

3
Q

time between onset of irregular AND permanent cessation of menses

A

perimenopause

4
Q

premature menopause before age 40

A

premature ovarian failure

5
Q

hormonal changes in perimenopause

A

decreased INHIBIN and increased FSH

6
Q

hormonal changes in established menopause

A

marked reduction in ESTRADIOL (plus dec inhibin and inc FSH too)

7
Q

first symptom of menopause

A

menstrual irregularities

8
Q

thin lola vs fat lola during menopause - anong difference

A

thin lola prone to DRYNESS; fat lola prone to hyperplasia and BLEEDING

9
Q

how to diagnose menopause

A

use signs and symptoms and physical exam

10
Q

treatment for asymptomatic women

A

NONE

11
Q

2 main indications of hormonal therapy

A

for symptomatic women AND to prevent osteoporosis and heart disease

12
Q

most effective treatment for vasomotor symptoms

A

LOW DOSE hormone therapy (ex. 0.3 mg CEE)

13
Q

route for those with liver problems

A

transdermal (0.25 mg transdermal estradiol)

14
Q

hormonal treatment for vulvovaginal symptoms

A

HRT including tibolone

15
Q

first line tx for mood disorders

A

not HRT but anti-depressants

16
Q

explain the “window of opportunity” concept

A

HT may be cardioprotective if started around the time of menopause and continued long-term

17
Q

risk for ________ (disease) is INCREASED in women on HRT

A

venous thromboembolism

18
Q

for women over 60 with rish of osteoporosis, must take ___

A

raloxifene, biphosphonates or strontium ranelate.. AND .8-1g calcium and 800 IU vitamin D

19
Q

differentiate advantages/disadvantages of two types of HRT regimens

A

CYCLIC has predicatble and controlled bleeding, CONTINUOUS has good compliance but irregular bleeding

20
Q

hormonal therapy for vasomotor sx, sexual well-bein, vulvovaginal symptoms

A

TIBOLONE 2.5 mg / day

21
Q

non-HT indicated for hot flushes with depression (SNRI class)

A

desvenlafaxine

22
Q

woman on HRT with persistent irregular BLEEDING –> how to evaluate

A

(+) ultrasound -> (+) hysteroscopy –> biopsy –> D&C