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Flashcards in haematology morphology Deck (17)
1

what type of cell is this 

neutrophil 

 

look for a segmented (polymorphic) nucleus and neutral staining granules – looks like a lilac stained cytoplasm

2

what type of cell is this 

eosinophil

 

looks like: Bi-lobed, bright orange /red granules in cytoplasm

3

what are the reasons for a raised neutrophil count (neutrophilia)? 

infection

trauma 

infarction 

4

why might an eosinophil count be raised? 

raised in parasitic infections, hypersensitivity reactions and often elevated in people with hypersensitive conditions (e.g. atopic rhinitis)

5

what type of cell is this 

this is a basophil 

it is a cell which is found infrequently in circulation and has large deep purple granules obscuring the nucleus

6

what is the function of a basophil 

Circulating version of tissue mast cell, mediate hypersensitive reactions, FcReceptors bind IgE, granules contain histamine and heparin

7

what type of cell is this 

this is a monocyte 

they are large cells which contain a single nucleus, faint staining granules, and are often vacuolated

 

M = Macrophage once entered a tissue 

8

what type of cell is this 

this is a lymphocyte 

Mature – small with condensed nucleus and rim of cytoplasm

generally speaking, they are roughly the same size as an RBC 

can become activated (often called atypical) which are large with plentiful blue cytoplasm extending round neighbouring red cells on the film, nucleus more ‘open’ structure

9

What is the function of a lymphocyte 

Numerous types and function (subtypes of B, T and NK)

Cognate response to infection

The brains of the immune system

10

how does immunophenotyping work 

uses the expression profile of proteins (antigens) on the surface of cells

11

what type of cell is the easiest to identify which regard to the stages of haematopoiesis 

an effector mature cell as they have a line of reference 

before that, the ability to differentiate into different specialised cells makes it more challenging and harder to identify 

e.g. multipotent/lymphoid/myeloid 

12

which type of cell has a higher regenerative ability - LT HSC or ST HSC?

LT HSC 

 

ST HSC goes on to divide into a multipotent cell which will become an oligolineage progenitor cell 

13

what type of cell do ALL mature cells derive from 

stem cells 

14

megakaryocytes produce what type of cell and where? 

platelets in the bone marrow 

15

the different types of white cells are 

neutrophil

eosinophil 

basophil 

lymphocyte 

monocyte 

16

what does this blood film show? 

 

the arrows should help to identify this abnormality 

This is POLYCHROMASIA 

- increased reticulocytes on blood sample 

can be identified by the blue-grey appearance of a slightly larger looking RBC 

occurs in response to anaemia 

17

anaemia can either be microcytic or macrocytic 

what does this blood film indicate