Hereditary Disorders of Coagulation Flashcards Preview

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Flashcards in Hereditary Disorders of Coagulation Deck (16)
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1
Q

Name the 3 hereditary disorders of coagulation:

A

Hemophilia A, von Willebrand Factor, Hemophilia B

2
Q

Name the 3 hereditary disorders of coagulation:

A

Hemophilia A, von Willebrand Factor, Hemophilia B

3
Q

Hemophilia A involves what clotting factor?

A

Factor VIII; people with Hemophilia A make factors that inhibit Factor VIII

4
Q

Hemophilia B involves what clotting factor?

A

Factor IX; people with heme B make factors that inhibit Factor IX

5
Q

Genetics of Hemophilia A and B

A

X-linked recessive; most women are carriers, most men are affected

6
Q

What is the most common bleeding disorder?

A

von Wilibrands

7
Q

What does von wilibrand factor do?

A

It’s a glycoprotein that sticks platelets together and to the injured endothelial surface; it also has a binding site for factor VIII, prolonging its presence in circulation

8
Q

How many types of Von wilibrands disease are there?

A

Three - type I, II, and III

9
Q

Describe each of the types of von Wilibrands disease.

A

Type I - bleeding limited primarily to mucosal membranes, not serious; most common. Type II - Moderate to severe bleeding, noticed in adolescents; Type III - major bleeding, discovered at infancy.

10
Q

Hemophilia A involves what clotting factor?

A

Factor VIII; people with Hemophilia A make factors that inhibit Factor VIII

11
Q

Hemophilia B involves what clotting factor?

A

Factor IX; people with heme B make factors that inhibit Factor IX

12
Q

Genetics of Hemophilia A and B

A

X-linked recessive; most women are carriers, most men are affected

13
Q

What is the most common bleeding disorder?

A

von Wilibrands

14
Q

What does von wilibrand factor do?

A

It’s a glycoprotein that sticks platelets together and to the injured endothelial surface; it also has a binding site for factor VIII, prolonging its presence in circulation

15
Q

How many types of Von wilibrands disease are there?

A

Three - type I, II, and III

16
Q

Describe each of the types of von Wilibrands disease.

A

Type I - bleeding limited primarily to mucosal membranes, not serious; most common. Type II - Moderate to severe bleeding, noticed in adolescents; Type III - major bleeding, discovered at infancy.