Herpetovirdae Flashcards Preview

D&T 1 Exam 1 > Herpetovirdae > Flashcards

Flashcards in Herpetovirdae Deck (24):
1

How do CMV and EBV initiate infections

By infection cells of the respiratory system and regional lymph nodes associated with the resp system (primary infection)

2

Structural properties of the virus

Double stranded DNA
Icosahedral Capsid
Envelopes with Glyoprotein spikes

3

Why called CMV?

Cytomegalic cells (enlarged size)
Large inclusions on nucleus (owl-eye)

4

Characteristics of CMV

Larger genomic DNA
DS DNA PLUS viral mRNA
Replication in variety of cells
Latent infection in monocytes, BM cells- reactivated by HIV
Virus progeny remains cell associated

5

Cytomegalic Inclusion Disease (CID)

Congenital infection -- CMV infects the fetus in utero; targets visceral organs

*most common virus caused congenital infection
*carrier state occurs -- virus is shed via secretions

6

CMV acquired newborn infections

acquired in birth canal -- last trimester CMV secreted in cervix -- reactivated latent infection
Mother's milk
Mostly asymptomatic unless newborn is immunosuppressed or premature

7

CMV in children and adults

asymptomatic
secretions are vehicles for transmission

8

Post-transfusion mononucleosis

cause of failure of kidney transplant

9

Reactivation of latent CMV

Result of pregnancy or AIDS
Unusual disease manifestations

10

CMV immunity

80% of adults over 35 have Abs
Most infections inapparent

11

CMV diagnosis

Urine, saliva
Sedimentation of urine
CMV IgM in serum - elevated during primary infections and reactivations but not a good indicator of primary

12

Is Acyclovir effective against CMV?

NO

13

Are there vaccines for CMV?

Live attenuated
Split Vaccines (just antigens)

14

Torch Complex

Toxoplasmosis
Other: Syphillis, Listeria
Rubella
Cytomegalic Inclusion Disease
Herpes Simplex

15

What is the receptor for EBV on B cells?

CD21

16

Viral Antigens found in cells infected with EBV

EBNA (regulatory)
VCA
MA
EA

** NOT ON OTHER HERPETOVIRUSUSES

17

What are the EBV glycoproteins?

gp350/200 -- late proteins that are part of the envelope that enable the attachment to CD21

18

How does EBV replicate?

Circularizes like a plasmid

19

What can EBV cause?

Burkitt Lymphoma
MONO
Nasopharyngeal carcinoma (chinese males)
Oral hair leukoplakia in AIDS patients

20

Burkitt

EBV + activation of MYC protooncogenes

21

MONO

Atypical lymphocytes (DOWNEY CELLS) correspond to large T lymphocytes that form in response to EBV infected B cells

1. LAD
2. Splenomegaly
3. Exudative Pharyngitis

* Heterophile abs
Monospot Test (neg may be CMV)

22

HHV6B

Roseola
Children

23

HHV7

Roseola
High fever
Disseminated rash

24

HHV 8

Kaposi Sarcoma
Slows opposites of infected and uninfected cells
IL-6 homolog