Flashcards in Herpetovirdae Deck (24):
How do CMV and EBV initiate infections
By infection cells of the respiratory system and regional lymph nodes associated with the resp system (primary infection)
Structural properties of the virus
Double stranded DNA
Envelopes with Glyoprotein spikes
Why called CMV?
Cytomegalic cells (enlarged size)
Large inclusions on nucleus (owl-eye)
Characteristics of CMV
Larger genomic DNA
DS DNA PLUS viral mRNA
Replication in variety of cells
Latent infection in monocytes, BM cells- reactivated by HIV
Virus progeny remains cell associated
Cytomegalic Inclusion Disease (CID)
Congenital infection -- CMV infects the fetus in utero; targets visceral organs
*most common virus caused congenital infection
*carrier state occurs -- virus is shed via secretions
CMV acquired newborn infections
acquired in birth canal -- last trimester CMV secreted in cervix -- reactivated latent infection
Mostly asymptomatic unless newborn is immunosuppressed or premature
CMV in children and adults
secretions are vehicles for transmission
cause of failure of kidney transplant
Reactivation of latent CMV
Result of pregnancy or AIDS
Unusual disease manifestations
80% of adults over 35 have Abs
Most infections inapparent
Sedimentation of urine
CMV IgM in serum - elevated during primary infections and reactivations but not a good indicator of primary
Is Acyclovir effective against CMV?
Are there vaccines for CMV?
Split Vaccines (just antigens)
Other: Syphillis, Listeria
Cytomegalic Inclusion Disease
What is the receptor for EBV on B cells?
Viral Antigens found in cells infected with EBV
** NOT ON OTHER HERPETOVIRUSUSES
What are the EBV glycoproteins?
gp350/200 -- late proteins that are part of the envelope that enable the attachment to CD21
How does EBV replicate?
Circularizes like a plasmid
What can EBV cause?
Nasopharyngeal carcinoma (chinese males)
Oral hair leukoplakia in AIDS patients
EBV + activation of MYC protooncogenes
Atypical lymphocytes (DOWNEY CELLS) correspond to large T lymphocytes that form in response to EBV infected B cells
3. Exudative Pharyngitis
* Heterophile abs
Monospot Test (neg may be CMV)