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Flashcards in Hodgkins lymphma Deck (17)
1

what is hodgkins lymphoma

malignant proliferation of lymphocytes characterised by the presence of reed sternberg cells

2

features

- painless, non tender, asymmetrical lymphadenopathy
- weight loss, pruritus, night sweats, fever
- alcohol pain

3

biochem findings

- normocytic anaemia
- oesinophilia
- raised LDH

4

staging system

ann arbor

5

how is ann arbor staging worked out

CT scanning of chest, abdomen and pelvis

6

outline Ann Arbor staging

stage 1 - cancer in a single region

stage 2 - indicates cancer is located in 2 separate regions; both affected areas are confined to one side of the diaphragm

stage 3 - indicates the cancer has spread to both sides of the diaphragm, including one organ or area near the lymph nodes of spleen

stage 4 - diffuse or disseminated involvement of one or more extra-lymphatic organs, including: bone marrow, liver, nodular involvement of lung

7

A/B

S

E

X

A/b - absence or presence of B symptoms

S - if disease has spread to spleen

E - used if disease is extranodal

X - used if large deposits, > 10 cm or whether the mediastinum is wider than 1/3 of the chest on x ray

8

name a hodgkins lymphoma clinical trial

RATHL

9

CTCAE

common terminology criteria for adverse effects

grades severity of side effects to held guide management

10

most common subtype in developed countries

nodular sclerosing

11

risk factors

- EBV infection
- postive fhx
- young adults from higher socio-economic class

12

1st line management

chemotherapy + radiotherap

13

histological subtype safely observed in asymptomatic relapses

nodular lymphocyte predominant

14

cytotoxic chemotherapy commonly used in Hodgkins, and many other cancers and is cardiotoxic in 10-30%

Doxorubicin

15

most common chemotherapy drug

Cisplatin

16

3 side effects of cisplatin and how to advise about them

-

17

other common SE cisplatin

- N+V
- pain at cannula site
- metallic taste in mouth
- lethargy
- kidney damage: drink 4-5 fluids daily