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Flashcards in HY Pharm 2 Deck (25)
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2
Q

Common SE of spironolactone

A

**Gynecomastia and hyperkalemia

3
Q

Selective estrogen receptor modulator (SERM) used for prevention of osteoporosis and currently being tested for treatment of breast cancer (Stars study)

A

*Raloxifene

4
Q

Non-steroidal estrogen agonist causes clear cell adenocarcinoma of the vagina in daughters of women who used it during pregnancy

A

*Diethylstilbestrol (DES)

5
Q

Converted to more active form DHT by 5 alpha-reductase

A

*Testosterone

6
Q

Product of proinsulin cleavage used to assess insulin production

A

*C-peptide

7
Q

Long acting insulin

A

*Ultralente (humulin U)

8
Q

Amino acid derivative for treatment of Type II diabetes

A

*Nateglinide

9
Q

Increase bone density, also being tested for breast CA tx.

A

*Raloxifene (SERM-selective estrogen receptor modulator)

10
Q

Used intranasally and decreases bone resorption

A

*Calcitonin (salmon prep)

11
Q

Drug that causes contraction of the uterus

A

*Oxytocin

12
Q

Distribution of histamine receptors H1, H2, and H3

A

*Smooth muscle; stomach, heart, and mast cells; nerve endings, CNS respectively

13
Q

Prototype antagonist of H1 and H2 receptors

A

*Diphenhydramine

14
Q

1st generation antihistamine that is highly sedating

A

**Diphendydramine

15
Q

2nd generation antihistamines

A

*Fexofenadine, loratadine, and cetirizine

16
Q

H2 blocker that causes the most interactions with other drugs

A

*Cimetidine

17
Q

5HT-1D/1B agonist used for migraine headaches

A

**Sumatriptan, naratriptan, and rizatriptan

18
Q

Agents for reduction of postpartum bleeding

A

**Oxytocin and ergonovine

19
Q

Agents used in treatment of carcinoid tumor

A

**Cyproheptadine

20
Q

5HT-3 antagonist used in chemotherapeutic induced emesis

A

Aprepitant, Ondansetron, granisetron, dolasetron and palonosetron

21
Q

Ergot alkaloid used as an illicit drug

A

*LSD

22
Q

Dopamine agonist used in hyperprolactinemia

A

*Bromocriptine

23
Q

Mediator of tissue pain, edema, inactivated by ACE, and may be a contributing factor to the development of angioedema

A

*Bradykinin

24
Q

Drug causing depletion of substance P (vasodilator)

A

*Capsaicin

25
Q

Prostaglandins that cause abortions

A

*Prostaglandin E1 (misoprostol) PGE2, and PGF2alpha

26
Q

Inhibitor of lipoxygenase

A

*Zileuton