Immunology

Question 1

List components of innate immune system.

Answer 1

Physical barriers, phagocytes, complement, interferon

Question 2

What type of macrophage is found in the liver?

Answer 2

Kupfer cells

Question 3

What PAMP does the TLR3 PRR bind?

Answer 3

Viral double stranded RNA

Question 4

What happens if the innate immune system is evaded?

Answer 4

get sick and/or acquired immune system takes over

Question 5

Name the interferon released by infected cells?

Answer 5

IFN alpha and beta

Question 6

Name a type of cytokine that attracts immune cells to inflamed tissue?

Answer 6

chemokine

Question 7

All leukocytes are identified by this molecule?

Answer 7

cluster of differentiation (CD) 45

Question 8

What cell initiates adaptive immunity?

Answer 8

phagocytes

Question 9

Compare the response of the adaptive immune system from first time to second time exposure?

Answer 9

first exposure response takes 7-10 days

the second response faster and stronger

Question 10

What is the difference between active and passive immunity?

Answer 10

active- exposure to antibody or vaccine

passive- immunoglobulin from mother to baby or transfusion

Question 11

What are two ways that complement is activated?

Answer 11

pathogen -innate

antibody- adaptive

Question 12

What two types of cells do B cells differentiate into?

Answer 12

plasma cells and memory B cells

Question 13

What is unique about NKCs?

Answer 13

NKCs kill cells that do not have an MHCI complex on them

Question 14

Where do mast cells reside?

Answer 14

skin, mucosa, conjunctiva, mouth, nose

Question 15

What cytokine promotes diapedesis of PMNs?

Answer 15

IL-8

Question 16

What receptors are found on mast cells?

Answer 16

Fc for IgE

Question 17

What are the factors that promote differentiation of platelets?

Answer 17

GM-CSF, IL-3, IL-6 (colony stimulating factor)