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Immunology/ Parasitology > Immunology Exam 3 > Flashcards

Immunology Exam 3 Flashcards

1
Q

Mechanism/s for cell damage in type II hypersensitivity

A

A. Classical complement cascade
B. Natural Killer Cells
C. Opsonization
D. ALL OF THE ABOVE

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2
Q

Incompatible blood transfusion could induce a hemolytic reaction that results in intravascular lysis of the RBC’s and release of _______ from lysed cells.

A

HEMOGLOBULIN

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3
Q

Production of _____ anitibodies may be due to…

A

A. Emergence of forbidden clone of B cells
B. Production of antibody against sequestered tissue
C. Indirection -induced change in the cell receptors
D. ALL OF THE ABOVE

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4
Q

The lack of immune response for self-antigens in the tissue is caused by:

A

A. Deletion of self reactive cells
B, Inactivating the cell (anergy)
D. A & B

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5
Q

This tolerance is unresponsive to self-antigens (all the endogenous antigens).

A

Natural Tolerance

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6
Q

Function of T suppressors cells is important in suppression.

A

True

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7
Q

Antibodies against antibodies called _________.

A

Anti-idiotype-antibody

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8
Q

In Graves’ disease, antibodies blood, the TSH (thyroid stimulating hormone) receptors on the thyroid gland.

A

True

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9
Q

Which of the following autoimmune disease is associated with butterfly rash on the face?

A

Systemic lupus (SLE, Red wolf)

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10
Q

Which of the following factors is/are involved in insulin dependent diabetes mellitus autoimmune disease?

A

A. Infection
B. HLA gene
C. A & B

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11
Q

Which one of the following biochemical/s is/are going to be reduced in Hashimoto’s Thyroiditis?

A

Thyroxin

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12
Q

Which of the following is called rheumatoid factor?

A

IgM-antibody against F-c portion of a patient’s own IgG

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13
Q

Auto-antibodies in double-strained DNA are typical findings in which of the following disorders?

A 
Do not have an answer here, choices: 
A. Rheumatoid arthritis 
B. Systemic lupus erythematosus 
C. Diabetes mellitus 
D. Ankylosing spondylitis
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14
Q

Multiple sclerosis is associated with which of the following types of hypersensitivity reactions?

A

III & IV

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15
Q

The antibodies in warm agglutinin type immune hemolytic anemia consist of which of the following classes of immunoglobulins?

A

IgG

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16
Q

Allografts of lymphoid tissue are particularly immunogenic because of the high content of

A

MHC class II expressing cells

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17
Q

An example of a type III immune complex disease is

A

Rheumatoid Arthritis (RA) and Scleroderma (SLE)

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18
Q

The localized reactions to injected antigens in the same body site such as booster shoot are called ________

A

Arthus reaction

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19
Q

A positive tuberculin skin test is an example of __________

A

A delayed type allergy

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20
Q

Contact dermatitis is caused by ________

A

Chemical absorbed by the skin

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21
Q

A graft transplanted between individual who are members of different species

A

Xenograft

22
Q

Factors that affecting the immune system and decrease the immune functions are as follow:

A

A. Chronic disease
C. Emotional stress
D. A & C

23
Q

Patient with severe immunodeficiency disease in both T-cells and B-cells compartment accept an allogenic bone marrow graft.

A

TRUE

24
Q

Natural antibodies have the following characteristics:

A 
A. Low affinity 
B. Low specificity 
C. Harmless 
D. have some rule for clearing infection 
E. ALL OF THE ABOVE
25
Q

In natural tolerance 95% of apoptosis (PCD) of T-cells found in:

A

Thymus

26
Q

Central Tolerance is within ________

A

Thymus

27
Q

Matching:

  1. Post-Streptococal (Glomerulonephritis); B
  2. Arthus Reaction; C
  3. Serum Sickness; A
  4. Contact hypersensitivity; D
A

A. Type III hypersensitive (systemic)
B. Immune complex disease
C. Type III hypersensitivity (local)
D. Type IV

28
Q

T suppressor cells prevent ______ to make antibodies, and also prevent _______ from maturing into T-cytotoxic cells.

A

B-cells, T cells

29
Q

Preexisting infections can have positive or negative effects on immune response.

A

TRUE

30
Q

This is an induce tolerance in which an animal will fail to respond to non-self antigens (all exogenous antigens) from outside the body that would normally be immunologic.

A

Acquired Tolerance

31
Q

Which of the following factors are involved in autoimmune disease

A

A. Infection
B. Hormonal
C. Genetic
D. ALL OF THE ABOVE

32
Q

These monkey antigens (Rh factor) are presented in _______ of humans and absent in the other ______.

A

85% & 15%

33
Q

Transfusion reaction may cause:

A

A. Destruction of the transfused cells by hemolysis opsonization
B. Increased phagocytosis
C. ALL OF THE ABOVE

34
Q

The antibodies in cold agglutinin type immune hemolytic anemia consist of which of the following classes of immunoglobulins?

A

IgM

35
Q

Insulin dependent diabetes mellitus is associated with which of the following hypersensitivity?

A

Type III

36
Q

Production of auto-antibodies may be due to ________.

A

A. Emergence of forbidden clone of B cells
B. Production of antibody against sequestered tissues
C. Infection-induced change in the cell receptors
D. ALL OF THE ABOVE

37
Q

Auto-antibodies to double-stranded DNA are typical findings in which of the following disorder?

A

Ankylosing spondylitis

38
Q

The lack of immune response for self-antigen in the fetus is caused by _________.

A

A. Deletion of self reactive cells
B. Inactivating the cell (anergy)
D. Both A & B

39
Q

In secondary responses the antibodies of which of the following classes of immunoglobulin is detected first?

A

IgM

40
Q

Which of the following is an antigen presenting cell?

A

Platelets

41
Q

Which of the following components of the complement primarily undergoes activation in the alternative complement pathway?

A

C3

42
Q

Type II hypersensitivity reactions involve production of ________.

A

IgG & IgM

43
Q

B cells are responsible for which allergies?

A

A. Asthma
B.Anaphylaxis
D. BOTH A & B

44
Q

Example/s of physiologic barrier/s to infection?

A

Oil and Skin

45
Q

Nonspecific host defense is associated with ______.

A

Saliva

46
Q

These leucocytes have no identifiable membrane markers, can fight against cancer and belong to innate immunity.

A

Natural Killer Cells

47
Q

This antibody has the lowest percent in blood circulation and has harmful effect.

A

IgE

48
Q

Interferon (IFN) can interfere with viral infection. Interferon is a protein made by viral infected cells that bind to adjacent cells, and make them to be resistant to viral infection.

A

FALSE

49
Q

IFN y can be produced by which on of the following cells?

A

Macrophages

50
Q

Some microbes may produce peptide antigens that are similar to and cross react with , self antigen. Immune response attacks against these self antigens and produce antibodies that can cross react with tissues. These finding are based on _______.

A

Theory of Sequestered antigens

51
Q

Prevalance of MS is _______ in tropical, and _____ in North Europe, and Central USA.

A

Low, High

52
Q

Immunosupprasive strategies for prolongation of allograft

A

Antigen specific Immunosuppression

Immunology/ Parasitology (3 decks)

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