Immunosuppressive drugs Flashcards Preview

IHO week 5 > Immunosuppressive drugs > Flashcards

Flashcards in Immunosuppressive drugs Deck (8)
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1
Q

4 drugs that:

Interact with glucocorticoid receptors

–> GRE (glucocorticoid response elements)

–> NFkB –> suppress transcription

A

Prednisone

Methylprednisolone

Betamethasone

Dexamethasone

2
Q

Inhibits calcineurin via

NFAT pathway by binding

Cyclophilon

–blocks T cell activation

A

Cyclosporine

3
Q

Inhibits calcineurin via

binding to FK506

–blocks T cell activation

A

Tacrolimus

4
Q

Anti-proliferative

binds mTor

blocks progression of cell cycle from G1–S

A

Sirolimus

5
Q

Metabolite is an inhibitor of inosine monophosphate dehydrogenase (IMPDH)

inhibits B-cells and T-cells

A

Mycophenolate

Mofetil

6
Q

Ig binds to thymocytes in circulation –> lymphopenia and impaired T-cell response

A

Anti-thymocyte globulin (ATG)

7
Q

Antibody to CD3 on TCR

blocks T-cell activation

A

Muromanab-CD3

8
Q

Anti IL-2R’s (CD25) antibodies

blocks active T-cells and subsequent B-cell activation

A

Daclizumab

Basiliximab