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Oncology > Immunotherapy > Flashcards

Flashcards in Immunotherapy Deck (6):
1

What is immunotherapy?

Artificial stimulation of the immune system to fight cancer. Target immune checkpoints (e.g. PD1)

2

Why does it cause SEs?

Blocks immune checkpoint control. think like 'taking the brakes off someone's immune system'
SEs therefore mimic autoimmune/ inflammatory disease

3

Give examples of SEs for:
Skin, GI, renal, endocrine, liver, eyes, resp, neuro, msk

Skin: rash (can mimic any kind)
GI: diarrhoea
Renal: glomerulonephritis
Endo: thyroid, pituitary (can be fatal)
Liver: hepatitis
Eye: acute uveitis
Resp: pneumonitis
MSK: arthralgia
Neuro: guillain-barre

4

What test is important re: pituitary SEs

Cortisol

5

What is the peak time for occurrence of immuno SEs

6-8 weeks post-treatment (but can occur <6 months after)

6

How can side effects be managed?
Why?

High dose steroids
Immunotherapy triggers immune activation, so immunosuppression (e.g. steroids) can help reduce this