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Flashcards in Infection Cure and stuff Deck (13)
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1
Q

How to identify infectious agents as cause of cancer

A

1) Tumour bearing host has evidence of infection
2) persistance evidence of viruses(DNA,RNA, proteins, viruses in culture) in tumour cells
3) Virus can transform cell in vitro
4) virus can induce tumours in experimental host

ULTIMATE- prevention of infection will prevent the

2
Q

Associations between virus and tumour

A

long latency periods
small percentage of infected progress
mutistep pathogenis
Virus is one link( break link stops cancer)

3
Q

Epsin Bar Virus(EBV) evidence for

A

majority fo population is infected
long life
transforms B-lymphoyets in culture

4
Q

EBV mechanism

A

Latent GenesLMP1 and LMP2A EBNA1, LMP, BArts, BARF1

Mimics Germinal centre reaction
LMP1- mimics CD40L:CD40: (T cell help)
LMP2A- mimics BCR interaction with antigen

5
Q

Diseases Caused by EBV

A

lymphoproliferative disease& immunoblastic Lymphomas
Endemic Burkett Lymphoma
Nasopharyngeal Carcinoma

6
Q

lymphoproliferative disease& immunoblastic Lymphomas

Characteristics and treatment

A

results of polyclonal B cell proliferation and monoclonal NHLs
no chromosonal changes

Expresses EBV late genes
Treatment- EBV specific cytotoxic T cells

7
Q

Endemic Burkett Lymphoma

A

all EBV genome postitive
c-myc translocation to IG heavy or light chains
not effected by t cell control
restricted latent gene seen- EBNA1

Treatment Chemo

8
Q

Nasopharyngeal carcimona

Characterictics and Treatment

A

Elevated EBV antibodies and EBV DNA- use as a prognostic marker
Greater resitricted latent gene expression
always associated with EBV
associated with diets- satled fish

9
Q

EBV epitlial carcinomas

mechanism

A

infects mutated epithelial cells unable to differentiate and express latent genes which drives phenotype

10
Q

Human Papiloma Virus Background

Early and late genes

A

Cevical cancer
Early genes- 1-7—- E5,6 associated with cancer
Late genes- L2 and L1

11
Q

Infection and diagnosis

A

infection via intercourse/skin to skin transmission
Pap smear to look at dyscaryotic scells
lesions of carnima to get stage- mild-moderate-sever dysplasia- carcinoma in situ

12
Q

Mechanism

A

Replicated in epithelial cells
Rb negatively regulates cyclin6- RB binds to E&
E6- cell death inhibitor- destroyes b53 and BAK(proapoptic factor)

13
Q

Treatment

A

vaccine clears infection, therefore prevents cancer