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Flashcards in Influenza Deck (7)
1

Explain antigenic shift and drift-

Shift: genetic reassortment for haemaglutinin or neuraminidase via coinfection with pigs, birds etc. No previous immunity
Drift: mutations in HA and NA proteins

2

Risk of death with H1N1 - swine flu

pregnancy
obesity
immunosupression
chronic underlying disease

3

Influenza which viral family?

Orthomyxovirus
ssRNA

4

Which protein is for attachment?

Haemagglutinin

5

How long do you shed the virus?

24-48 hours prior to developement of symptoms, and for 6-8 days after the onset.
Incubation time is about 2 days ususally

6

How do the neuraminidase inhibitors work and what is their effect?

Inhibit the cleavage of the virus from sialic acid-->block release of new virus.

Reduce duration of sx by 1.5 days
Some studies have also shown reduction in antibiotic use and influenza related complications

H1N1 resistant to oseltamivir but STILL sensitive to Zanamavir

7

How effective is the influenza vaccination?

70% for one year
Targets are the haemagluttinins