Intestinal Pathology Flashcards Preview

GI 2 > Intestinal Pathology > Flashcards

Flashcards in Intestinal Pathology Deck (17)
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1
Q

Surgical tx for IBD

A

Common for Crohn but NOT UC

2
Q

Crohn

A

Any part of GI tract

Thickened wall

Fistula

Granuloma

String sign on -ray

3
Q

UC

A

Limited to colon (backwash ileitis)

Rectal involvement

Broad-based ulcers with pseudopolyps

Severe mucosal inflammation with crypt abscesses

4
Q

Celiac

A

Sensitive to gluten

T cell mediated chronic inflammatory rxn with AI component

Impaired nutrient absopriton

Iron def anemia is most common in adults

5
Q

Whipple dz

A

Rod shaped bacteria within lymphoid tissues

Tropheryma whippeli

Mostly middle aged white males

PAS pos, diastase resistant

Bacilliform bodies on EM

6
Q

Ischemic bowel dz

A

Trnasmural - major mesenteric vessels…sudden and severe pain

Mural and mucosal - hypoperfusion…IM and nonspecific ab complaints with bloody diarrhea

From arterial obstruction (severe athersclerosis)

Intestinal hypoperfusion

7
Q

Ischemic bowel dz locations

A

Colon - splenic flexure b/t mesenteric arteries

8
Q

Pesudomembrane colitis

A

Acute, inlam from C. dif

Volcano or mushroom like

Hx of recent AB use

9
Q

Collagenous colitis

A

Middle-aged and older female

Chronic watery diarrhea

Normal colonoscopy

Thickened subepithelial collagen layer

10
Q

Hemorrhagic E. coli colitis

A

Most common infectious bloody diarrhea cause in US

Inadequately cooked hmaburder

Right colon is most common

11
Q

Hyperplastic polyp

A

Rectosigmoid area
Small
Older
Sawtoth on surface

12
Q

Juvenile polyp

A

Sporadic or JPS

Under 5 y/o

13
Q

Hamartomatous polyp

A

Localized overgrowth of normal gladns and smooth muscle

Peutz-Jeghers syndrome

14
Q

Tubular adenoma

A

Pedunculated
Pseudostratification with enlarged nucelli and hyperchoromasia

Most common

15
Q

Villous adenoma

A

No stalk and finger like projections

16
Q

Adenoma-carcinoma sqeunce

A

1) APC/Beta-catenin
2) microsatellitle instability
3) DNA methylation pathway

17
Q

Diverticulosis

A

Elderly
Sigmoid colon
Acquired, low fiber diet