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Pharmacy (year one) > Intracellular receptors > Flashcards

Flashcards in Intracellular receptors Deck (15)
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1
Q

Intracellular receptors are membrane bound, True or false?

A

False - not membrane bound

2
Q

Intracellular receptors are important in directly regulating ____ expression

A

gene

3
Q

Intracellular receptors are also known as __________ or __________

A

nuclear hormone receptors

nuclear transcription factors

4
Q

Sometimes the DNA binding region is called _______

A

zinc fingers

5
Q

The ligand binding site is at which terminal?

A

C-terminal

6
Q

The DNA binding region contains ____ cysteine residues

A

9

7
Q

How many of the cysteine residues can bind zinc ions?

A

8

8
Q

Zinc ions destabilise the DNA binding region. True or false?

A

False - they stabilise it

9
Q

How do intracellular receptors work?

A

ligand crosses the membrane, seeks a receptor and binds
Induced fit takes place and receptor changes shape - dimerisation
Dimer then binds a coactivator
Whole complex then binds to a specific region of the cell’s DNA

10
Q

What is oestrodiol?

A

A steroid hormone that affects the growth and development of tissues

11
Q

Oestrodiol uses its phenol and alcohol groups to form ______ bonds with three amino acids in the binding site

A

Hydrogen

12
Q

Breast cancer is _________ dependent

A

oestrogen

13
Q

What are the three ways in which oestrogen secretion can be reduced?

A

Oophorectomy
Hypophysectomy
Adrenalectomy

14
Q

Is taximofen a competitive or non-competitive inhibitor?

A

Competitive - it inhibits the binding of oestrogen to oestrogen receptors

15
Q

For oestrogen positive tumours, one year treatment with tamoxifen reduces recurrence and increases survival. True or false?

A

True

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