Introduction to Autonomic Pharmacology Flashcards Preview

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Flashcards in Introduction to Autonomic Pharmacology Deck (18)
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1
Q

Name some ANS NT

A

Acetylcholine and norepinephrine

2
Q

Sympathetic and parasympathetic messengers

A

Sympathetic - preganglionic releases ACh…binds nicotinic…release NE…binds adrenergic

Parasympathetic - preganglion releases Ach…binds nicotinic…releases Ach….binds muscarinic

3
Q

Symp and parasymp organization

A

Sym - thoracolumbar with short - ganglion - long

Parasymp - craniosacral with long - ganglion short

4
Q

Both SNS and PNS are connected to CNS via the

A

hypothalamus which receives connections from limbic structures

5
Q

Dorsal longitudinal fasculus

A

Midbrain, pons, and medulla

6
Q

ANS not only composed of efferents

A

Reflexes

Baroreceptors reflex, carotid bodies, chemoreceptors, and stretch receptors (micturition)

7
Q

Medullary cardiovascular center

A

Nucleus tractus solitarius (vasomotor area)…baroreceptors from carotid sinus and aortic arch stretch

8
Q

Parasympathetic nervous system carries

A

Dominant tone at rest while sympathetic carries fight or flight

9
Q

Divergence of symp and parasymp

A

Symp - diffuse output

Parasymp - discrete because only one organ

10
Q

Cholinergic transmission

A

Action potential…presynaptic depolarization…Ca entry…vesicle fusion…NT release

11
Q

M1 receptor

A

Nerves, enteric ganglia

GPCR

Uses IP3 and DAG

12
Q

M2 receptor

A

Heart, nerves, smooth muslce

GPCR

Inhibition of cAMP, K= channel activaiton

13
Q

M3 receptor

A

Glands, smooth muscle, patietal, endothelium

GPCR

IP3 and DAG cascade

14
Q

Nm receptor

A

Skelatal muscle NMJ

Na+, Ca depolarizing ion channel

15
Q

Nn

A

Postganglionic cell body

Na, Ca depolarizing ion channel

16
Q

Nicotinic vs. muscarinic structure

A

Nicotinic - ligand gated ion channels

Muscarinic - GPCR

17
Q

Adrenergic receptor NTs

A

Epi, NE, dopamine

18
Q

Termination of signal for adrenergic

A

NET (NE transporter…basically reuptake) - 85%
ENT (extraneuronl amine transporter) - 15%
Diffusion - 10%