Iron and Copper Nutrition

Question 1

Two oxidative states of iron

Answer 1

Fe2+ = ferrous
Fe3+ = ferric

Question 2

Oxidative states of iron

interconversions

Answer 2

dietary: Fe3+
absorbed: Fe2+ (converted by brush border enzyme)
blood: Fe3+ bound to transferritin

Question 3

Fe3+ transported in blood via

Answer 3

transferritin

Question 4

Iron stored in enterocytes bound to

Answer 4

ferritin

Question 5

Regulation of Fe absorption

Answer 5

HFE gene, hepcidin
high iron --> activates HFE gene
hepcidin produced in liver
hepcidin binds ferroportin on basolateral surface of enterocytes
degradation of ferroportin
decreased iron uptake

Question 6

Hemochromatosis etiology

Answer 6

HFE gene mutation

inability to produce functional hepcidin and therefore degrade ferroportin

Question 7

Copper oxidative states

Answer 7

Cu2+ –> Cu+ via brush border enzymes

Question 8

CTR1

Answer 8

transporter on apical surface for Cu

Question 9

Menkes kinky hair syndrome

Answer 9

ATP7A mutation
decreased uptake of Cu
hair normal at birth -> becomes brittle and sparse w/ age
hypothermia, hypotonia, FTT, seizures

Question 10

Wilson disease

Answer 10

ATP7B mutation
normally transports excess iron into bile for excretion
chelation Tx