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Clinical Pharm > IV Anesthetic Agents > Flashcards

IV Anesthetic Agents Flashcards

1
Q

Propofol class

A

Sedative hypnotic

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2
Q

Propofol MOA

A

GABA-A

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3
Q

Propofol intubating dose

A

1-3 mg/kg

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4
Q

Propofol bolus dose

A

10-50 mg

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5
Q

Propofol infusion dose

A

50-300 mcg/kg/min

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6
Q

Etomidate class

A

Non-barb. Hypnotic

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7
Q

Etomidate MOA

A

GABA-A

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8
Q

etomidate intubating dose

A

0.2-0.4 mg/kg

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9
Q

Etomidate considerations (4)

A

Decrease CMRO2
Decrease CBF
Causes adrenal suppression
Cardiac stability

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10
Q

Ketamine class

A

Dissociative anesthetic

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11
Q

Ketamine MOA

A

NMDA antagonist

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12
Q

Ketamine IV intubating dose

A

0.5-2 mg/kg

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13
Q

Ketamine IM intubating dose

A

4-10 mg/kg

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14
Q

Ketamine bolus dose

A

10-30 mg

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15
Q

Ketamine considerations

A
  • bronchodilator

- Increase HR, BP, CO

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16
Q

Thiopental class

A

Barb

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17
Q

Thiopental MOA

A

GABA-A

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18
Q

Thiopental intubating dose

A

3-5 mg/kg

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19
Q

Thiopental considerations (3)

A

Decrease CMRO2
Decrease CBF
– BP

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20
Q

Methohexital class

A

Barb

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21
Q

Methohexital MOA

A

GABA-A

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22
Q

Methohexital intubating dose

A

1-2 mg/kg

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23
Q

Methohexital considerations

A

Apnea

Eye block: cardioversion

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24
Q

Remifentanil class

A

Opiate

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25
Q

Remifentanil MOA

A

Mu agonist

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26
Q

Remifentanil intubating dose

A

0.5-1 mcg/kg/min - intubate after 8 min

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27
Q

Remifentanil drip dose

A

0.02-0.2 mcg/kg/HR

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28
Q

Remifentanil considerations

A

Dose IBW for obese patients

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29
Q

Precedex MOA

A

Alpha 2 agonist

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30
Q

Precedex intubating dose

A

0.5-1.0 mcg/kg over 10-30 minutes

31
Q

Precedex drip rate

A

0.2-1.0 mcg/kg/hr

32
Q

Precedex considerations

A

Causes sedation without respiratory depression

33
Q

Propofol concentration

A

10 mg/ml

34
Q

Propofol onset

A

30-60 sec

35
Q

Propofol duration

A

2-8 minutes

36
Q

Propofol metabolism

A

Liver/kidney

37
Q

Propofol T 1/2

A

1-2 hours

38
Q

Propofol adverse effects

A

Decreased BP, HR, contractility, PRIS

39
Q

Etomidate concentration

A

2 mg/ml

40
Q

Etomidate onset

A

60 seconds

41
Q

Etomidate duration

A

3 min

42
Q

Etomidate metabolism

A

Liver:kidney

43
Q

Etomidate T 1/2

A

3-5 hours

44
Q

Etomidate adverse effects

A

PONV

Myoclonus

45
Q

Ketamine concentrations

A

50 mg/ml

46
Q

Ketamine onset

A

60 sec

47
Q

Ketamine duration of action

A

5-10 min

48
Q

Ketamine metabolism

A

Liver

49
Q

Ketamine T 1/2

A

2-3 hours

50
Q

Ketamine adverse effects

A

Increased secretions

Emergence delirium

51
Q

Thiopental concentration

A

25 mg/ml

52
Q

Thiopental onset

A

30-60 min

53
Q

Thiopental duration

A

10-30 min

54
Q

Thiopental metabolism

A

Liver

55
Q

Thiopental T 1/2

A

10-12 hours

56
Q

Thiopental adverse effects

A

Induces CYP450
Decreases BP
No barbs in pt’s with porphyrias

57
Q

Methohexital concentration

A

10 mg/ml

58
Q

Methohexital onset

A

30-60 min

59
Q

Methohexital duration

A

5-10 min

60
Q

Methohexital metabolism

A

Liver

61
Q

Methohexital T 1/2

A

4 hours

62
Q

Methohexital adverse effects

A

No barbs in pt’s with porphyrias

63
Q

Remifentanil concentration

A

50 mcg/ml

64
Q

Remifentanil onset

A

60-90 seconds

65
Q

Remifentanil duration

A

4-8 minutes

66
Q

Remifentanil metabolism

A

RBC/Tissue esterase

67
Q

Remifentanil T 1/2

A

Rapid off

68
Q

Remifentanil adverse effects

A

Hyperalgesia

Apnea

69
Q

Precedex concentration

A

100 mcg/ml

70
Q

Precedex onset

A

5-10 min

71
Q

Precedex metabolism

A

Liver/kidney

72
Q

Precedex T 1/2

A

2-3 hours

73
Q

Precedex adverse effects

A

Decreased HR, BP

Alpha 2: alpha 1 = 1620:1

Clinical Pharm (10 decks)

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