K+ and Ca2+ Channel Blockers--Nordgren Flashcards Preview

CRRAB--Wk 4 > K+ and Ca2+ Channel Blockers--Nordgren > Flashcards

Flashcards in K+ and Ca2+ Channel Blockers--Nordgren Deck (12)
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1
Q

What is the function of Class III Drugs?

A

K+ blockers

prolong repolarization

K+ responsible for repolarizing AP

2
Q

What type of arrhthmia are K+ channel blockers best for?

A

reentry

3
Q

Most important adverse effect of amiodarone

A

dose-related pulmonary toxicity

4
Q

What are Class IV antiarrythmatic drugs?

A

Ca2+ channel (L-type) blockers

5
Q

What type of Ca2+ channels do class IV drugs affect?

A

L-type

6
Q

What are the 2 subtypes of Ca2+ channel blockers?

A

dihydropyridines (sm muscle)

non-dihydropyridines

7
Q

Dihydropyridines are in what general class?

what do they function to do?

A

Class IV: Ca2+ channel blockers

act on sm. muscle

decreased contractility of sm. muscle

8
Q

Non-dihydropyridines are in what general class?

what is their function?

A

class IV: Ca2+ channel blockers

act specifically on cardiac cells

9
Q

Non-dihydropyridines act on cardiac tissue how?

A

myocytes: decreases Ca2+ buffering of repolarization, decreasing refractory period

nodal cells: decreases ability to self-generate AP, prolongs refractory period –> decrease heart rate

10
Q

MOA: Adenosine

A

activation of K+ channels and inhibition of L-type Ca2+ channels

leads to hyperpolarization of cardiac myocytes

suppresses AV conduction and increases AV refractory period

11
Q

What is adenosine used for?

A

supraventricular tachycardias

12
Q
A