Lab evaluation of hemostasis Flashcards

1
Q

Which blood tube is platelet count taken from?

A

Lavender top

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2
Q

What might a high platelet count mean?

A
Acute phase reaction
Early CML
Essential thrombocytosis
Polycythemia vera
Post-splenectomy
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3
Q

What might a low platelet count mean?

A
DIC
Hemolytic anemia
Hypersplenism
ITP
Leukemia
Prosthetic heart valve
Recent transfusion
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4
Q

Bleeding time

A

Measures how well platelets interact with blood vessel walls to form clots.
Used to dx vWD

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5
Q

Bleeding time procedure

A

make 5mm x 1mm deep puncture
blot q 30 seconds until clot
avoid aspirin 2 weeks prior
Normal is 3 - 8 mins

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6
Q

What might a high bleeding time mean?

A
platelet dysfxn
DIC
Leukemia
Liver disease
thrombocytopenia
vWD
Vasculitis
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7
Q

Prothrombin Time (PT)

A

Measures vitamin K dependent clotting ability and extrinsic pathway.
Used to screen for bleeding disorders
used to monitor patients on warfarin
INR normalizes results

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8
Q

PT collection

A

Light blue top
Fill completely
correct ratio of blood to citrate

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9
Q

Normal PT

A

PTT: Adults: 11 - 13 seconds
INR: < 2

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10
Q

what might a high PT mean?

A
anti-phospholipid antibody syndrome
DIC
Liver disease
Vitamin K deficiency
Factor II, V, VII or X deficiency.
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11
Q

what does activated partial PT measure?

A

Intrinsic pathway

VIII, IX, XI and XII

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12
Q

What might high PTT mean?

A
hemophilia
DIC
liver disease
Vitamin K deficiency
Heparin therapy
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13
Q

Thrombin Time

A

Measure of the fibrinolytic pathway
Rate of conversion of fibrinogen to fibrin.
Normal is 15 - 20 seconds

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14
Q

what might a high thrombin time mean?

A
DIC
Liver disease
dysfibrinogenemia
paraproteinemia
Uremia
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15
Q

what might Low thrombin time mean?

A

erythrocytosis

dysfibrinogenemia

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16
Q

Clinical signs of platelet deficiency

A
Gum bleeding
Epistaxis
Petechiae
Prolonged bleeding from minor cuts
Abnormal bleeding time
Normal PT/PTT
17
Q

Clinical signs of factor deficiencies

A
Hemarthrosis
Delayed bleeding
Post-op hemorrhage
Muscle hematoma
Normal bleeding time
Abnormal PTT