Lec 18 Fever in the Immunocompromised Host Flashcards Preview

OS 217 Infectious Diseases > Lec 18 Fever in the Immunocompromised Host > Flashcards

Flashcards in Lec 18 Fever in the Immunocompromised Host Deck (20)
Loading flashcards...
1
Q

dirtiest areas in our bodies

A

mouth and large intestine

2
Q

cytotoxic agent that affects VEGF

A

bevacizumab

3
Q

febrile neutropenia criteria

A

Fever of >38.30C OR sustained fever ≥ 380C for 1 hour or more

AND

Absolute neutrophil count

4
Q

cytotoxic agent that affects EGFR

A

cetuximab

5
Q

cytotoxic agent that affects CD33

A

gemtuzumab

6
Q

cytotoxic agent that affects HER2

A

trastuzumab

7
Q

Prevention for high-risk patients with expected durations of prolonged and profound neutropenia (Absolute Neutrophil Count

A

Fluoroquinolone Prophylaxis

8
Q

Prevention for those undergoing allogenic stem cell transplant and For those undergoing remission-induction or salvage induction chemotherapy for acute leukemia

A

Anti-Candida Prophylaxis

9
Q

Prevention for those undergoing extensive chemotherapy for acute myelogenous leukemia or myelodysplastic syndrome

A

Posaconazole Prophylaxis

10
Q

Prevention for herpes simplex virus (HSV)-positive patients undergoing allogenic stem cell transplant or leukemia induction therapy

A

Acyclovir Prophylaxis

11
Q

leading cause of cell-mediated immunity suppression

A

HIV

12
Q

Requires the least amount of immunosuppression among all transplant organs

A

kidney transplant

ps. pag nakarating ka na dito, pakyu ka

13
Q

Requires the highest amount of immunosuppression among all transplant organs

A

heart and intestines

14
Q

First-line immunosuppressants

A

Calcineurin Inhibitors and Anti-proliferative agents

15
Q

Immunosuppression peaks during the first ____ months post-transplant

A

6

16
Q

Used for autoimmune diseases such as inflammatory bowel disease, rheumatoid arthritis, and psoriasis.

A

TNF agonists

17
Q

targets CD20 found in B cells

A

rituximab

18
Q

Why does DM cause increased infection?

A
  1. hyperglycemia effects
  2. Breaks in cutaneous and mucosal barrier due to microvascular angiopathy
  3. Neuropathy which diminishes pain sensation
19
Q

Immune changes as we get older

A
  1. Functional change in T cell subsets, with a decrease in IL-2 secretion
  2. Naive T cells have decreased ability to respond to new antigens
  3. Humoral immunity mildly affected
20
Q
Which of these can cause impairments in antibody-mediated immunity?
A.	Multiple myeloma
B.	Chronic lymphocytic leukemia
C.	Splenectomy
D.	Rituximab treatment
E.	AOTA
A

E