Lecture 1 Flashcards Preview

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Flashcards in Lecture 1 Deck (7)
1

What factor is released by cellsduring hypoxia

HIF-1
hypoxia ind factor 1

2

What are some genes regulated by HIF-1

GLUT1
GLUT3

Growth factors. VEGF IGF2

Glycolysis enzymes
Phosphofructokinase
Hexokinase
Lactate dehydrogenase

3

What diseases does hypoxia play a pathogenic role?

Ischemia...

COPD
Malignant tumors
Atherosclerosis
Diabetes mellitus
Inflammatory diseases
Psoriasis
Pre-ecllampsia

4

How are ROS generated?

By the incomplete reduction of oxygen (O2)

5

What are the categories disorders of major homeostasis? (6)

Oxygen

Redox and antioxidant

Immunohomeostasis

Cell volume regulation

pH homeostasis

Hemostasis

6

Functions of the ER

Protein synthesis

Lipid synthesis

Biotransformation

Ca++ storage

Production of glucose

Protein synthesis for secrion, ER secretory pathway

Heme synthesis

7

Potential responses to organelle stress

Adaptation
Unfolded protein response (ER response)
Mitochondrial Stress response

Death
Apoptosis
Necrosis