Flashcards in lets get drunk Deck (31)
what is the definition of alcohol
organic liquid with hydroxyl OH group
where can methanol be found?
home brewed alcohol
what are the chemical processes of methanol
metabolised to formaldehyde (by alcohol dehydrogenase) and then formic acid (by aldehyde dehydrogenase)
does methanol have depressant properties
why does ethanol treat methanol toxicity?
ethanol is a competitive inhibitor which acts on acetyl dehydrogenase - therefore ethanol competes with formaldehyde acetate is produced instead of formic acid
what is the drinking recommendation for alcohol
14 units but dont consume in 3 continuous days
why shouldnt you drink on an empty stomach?
alcohol is mainly absorbed in the small intestines, if it is in the stomach for longer it is metabolised more
what can increase gastric emptying and increase absorption
antihistamines and metoclopramide
what can iritate gastrric mucosa and delay emptying
which kind of drinks are absorbed faster
what are some symptoms of alcohol poisoning
blindess and renal failure
what is the quickest absorption on an empty stomach?
why do females get drunker quicker?
- females have higher subcut fat % (they dont have a higher BMI)
- males have more lean mass and a higher blood volume, even for the sae weight
- women have lower levels of alcohol dehydrogenase
what is the pathway for alcohol metabolism
alcohol - alcohol dehydrogenase
acetaldehyde - aldehyde dehydrogenase
CO2 and H2O
at which speed is alcohol removed from the blood?
how does alcohol concentration peak and trough
peaks at 60mins
then decerases linerary
which ethnic minorities have low or absent levels of alcohol and aldehyde dehydrogenase
aboriginies inunits, eskimos, japanese
what are the symptoms of alow levels of alcohol dehydrogenase
flushing, warm face, sick
what does antabuse do?
inhibits aldehyde dehydrogenase (making drinking unpleasent)
which paths are activated by heavy drinking
MEOS, catalase and induction of CP450
what does MEOS do
produces hydrogen ions so switch to anaerobic metabolism (more likely to produce lactic acid / less glucose) and leads to hepatic gluconeogenesis = hungry
what is alcoholic ketoacidosis?
associated with malnourished state
low/normal glucose and HIGH ketones
does alcohol increase or decrease GABBA?
increases - inhibits neurotransmittors more
what controls talkativeness
what controls muscular coordination and speech
what controls conciousness
upper brain stem
what does ADH Do
promotes water reabsorptin within distal tubule - causes concentrated urine
does alcohol inhibit or promote ADH
is alcohol a positive or negative inotrope
negative - heart beats faster to maintain same cardiac output