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Flashcards in lets get drunk Deck (31)
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1

what is the definition of alcohol

organic liquid with hydroxyl OH group

2

where can methanol be found?

home brewed alcohol

3

what are the chemical processes of methanol

metabolised to formaldehyde (by alcohol dehydrogenase) and then formic acid (by aldehyde dehydrogenase)

4

does methanol have depressant properties

yes

5

why does ethanol treat methanol toxicity?

ethanol is a competitive inhibitor which acts on acetyl dehydrogenase - therefore ethanol competes with formaldehyde acetate is produced instead of formic acid

6

what is the drinking recommendation for alcohol

14 units but dont consume in 3 continuous days

7

why shouldnt you drink on an empty stomach?

alcohol is mainly absorbed in the small intestines, if it is in the stomach for longer it is metabolised more

8

what can increase gastric emptying and increase absorption

antihistamines and metoclopramide

9

what can iritate gastrric mucosa and delay emptying

spirits

10

which kind of drinks are absorbed faster

aerated drinks

11

what are some symptoms of alcohol poisoning

blindess and renal failure

12

what is the quickest absorption on an empty stomach?

20-30%

13

why do females get drunker quicker?

- females have higher subcut fat % (they dont have a higher BMI)
- males have more lean mass and a higher blood volume, even for the sae weight
- women have lower levels of alcohol dehydrogenase

14

what is the pathway for alcohol metabolism

alcohol - alcohol dehydrogenase
acetaldehyde - aldehyde dehydrogenase
acetate
CO2 and H2O

15

at which speed is alcohol removed from the blood?

15mg/100ml/unit/hour

16

how does alcohol concentration peak and trough

peaks at 60mins
then decerases linerary

17

which ethnic minorities have low or absent levels of alcohol and aldehyde dehydrogenase

aboriginies inunits, eskimos, japanese

18

what are the symptoms of alow levels of alcohol dehydrogenase

flushing, warm face, sick

19

what does antabuse do?

inhibits aldehyde dehydrogenase (making drinking unpleasent)

20

which paths are activated by heavy drinking

MEOS, catalase and induction of CP450

21

what does MEOS do

produces hydrogen ions so switch to anaerobic metabolism (more likely to produce lactic acid / less glucose) and leads to hepatic gluconeogenesis = hungry

22

what is alcoholic ketoacidosis?

associated with malnourished state
excess NADH
low/normal glucose and HIGH ketones

23

does alcohol increase or decrease GABBA?

increases - inhibits neurotransmittors more

24

what controls talkativeness

cortex

25

what controls muscular coordination and speech

cerebellum

26

what controls conciousness

upper brain stem

27

what does ADH Do

promotes water reabsorptin within distal tubule - causes concentrated urine

28

does alcohol inhibit or promote ADH

directly inhibits

29

is alcohol a positive or negative inotrope

negative - heart beats faster to maintain same cardiac output

30

what is holiday heart syndrome

binge dirnking leads to SVT with spontaneous resolution