Liver Pathology Flashcards Preview

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Flashcards in Liver Pathology Deck (11)
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1
Q

Acinar zones

A

1 - periportal
2 - midzonall
3 - centrilobular (most likely to get ischemia)

2
Q

Necorsis in the liver

A

Acidophil bodies - apoptosis

Zonal necrosis - centriblobular is most common
Midzonal for yellow fever
Periportal for phosphorus

3
Q

Causes of centrilobular necrosis of the liver

A

Hypotension
CHF
Drug toxicity (tylenol)

4
Q

Mech of acetominophen OD

A

Acet normal excreted as glucouronate and sulfate

Alcoholics havbe more CYP2E1…convert to NAPQI…less glutathione

5
Q

Interface hepatitis

A
Hep C
Hep B 
AI hep
Primary biliary and scelorising cholangitis 
alpha 1 AT
6
Q

Cirrhosis

A

Diffuse, bridging fibrosis and regenerating nodules

Could be from alcoholic liver dz
Hep B or C (C more common)
NAFLD

7
Q

CM of cirrhosis

A

IMpaired hepatic metab of estrogen

Impaired synthesis of albumin and coagulation

Hepatorenal syndrome

8
Q

FLD etiologies

A

Alcoholic

Non alcoholic from obesit yor T2DM

See fatty liver
Steatohepatitis - alcoholic or NASH
cirrhosis

Occur sequentuially

9
Q

Drug and toxin induced liver injury

A

Indistinuishable from other etiologies

10
Q

Echinacea

A

Herbs that supposedly increase immune system

11
Q

Green tea extract

A

Smarter, burn fat, antioixdants