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SADL Oncology > Lymphoma > Flashcards

Flashcards in Lymphoma Deck (17):
1

Burkitt's immunophenotype and cytogenetics

surface immunoglobulin +
TdT negative
CD 19, 20, 22 +
Most CD 10+

Cytogenetics:
(8;14)
(8;22)
(2;8)

2

Lymphoblastic lymphoma immunobiology

B cell: Tdt positive, CD19, CD79a, or CD22 positive. HLA-DR +

T-cell: cytoplasmic or membrane CD3, TdT+, HLA-DR and CD34 negative

7

3

What are the risk factors for hodgkins lymphoma?

Family Hx
EBV infection
SES- for those with HL <10yrs associated with low SES and crowding, but in young adults associated with high SES and fewer exposures to children
social contacts

4

what are the types of classic HL?

Nodular sclerosing
mixed cellularity
lymphocyte rich
lymphocyte depleted

5

what is the immunophenotype of classic HL

CD30+
CD15+ (70%)
CD45 neg
CD20+ (20-30%)
Pax5+

6

what is the immunophenotype of NLPHL?

CD30 neg
CD15 neg
CD45+
CD20+
CD79a +
Pax5 +

7

what is the definition of constitutional symptoms?

more than 10% weight loss in the last 6mths
drenching night sweats
fever >38C for more than 3 days and unexplained

8

what factors are associated with more of an adverse outcome in HL?

advanced stage
B symptoms
bulk disease
poor response to therapy

9

what does brentuximab target?

CD30

10

what cancer can transform in patients with NLPHL?

DLBCL

11

describe the lugano criteria

1-no uptake above background
2-uptake mediatstinum but liver
5-uptake markedly >liver and or new lesions

1 and 2= CR
3-context dependent
4 and 5= active disease

12

what is the ddx for mediastinal mass?

normal thymus
infection-EBV, atypical mycobacterium, histoplasmosis, toxoplasmosis
lymphoproliferative disease
malignant- HL, Lymphoblastic lymphoma, DLBCL, ALCL, primary mediastinal Bcell lymphoma, germ cell tumour, soft tissue sarcoma, lymph node met from other sites

13

what translocation is associated with ALCL?

t(2;5)
NPM-ALK

14

what translocations are associated with Burkitts lymphoma

8;14-most common
2;8
8;22

15

what is the immunophenotype of DLBCL?

sIg+, light chain restricted
CD19, CD20, CD22, CD79a, PAX-5 +
Can be CD30+
2/3 express BCL-6
1/3 express cMYC

16

BCL-6 is expressed by which NHL, and what can it be used to differentiate sometimes between?

BCL-6 is expressed by DLBCL but not by Burkitts

17

Which NHL is least likely to be associated with EBV?

ALCL