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Flashcards in Lymphoma Stuff Deck (14)
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1
Q

PMLE

A

CD8

2
Q

MC cell in MF

A

T helper

3
Q

MC COD in MF

A

Sepsis

4
Q

Prognostic factors in MF

A

LAD, tumors, ulceration

If all 3 median survival is 1 yr

5
Q

MF may manifest with

A

TNF inh

6
Q

Incr risk of MF

A

AD

7
Q

MF markers

A

Cutaneous lymphocyte ag (CLA) - E selectin ligand, allows traffic into skin

CCR4, another homing molecule

Incr APCs and incr capacity to + T cells

Th1 pattern

more CD8 in early lesions to fight off - more than 20% CD8 in MF have impr survival

Sezary is Th2 which reduces th fxn = incr infection and 2’ CA

Low hhv8 has been detected

Cd4+, cd7-, cd26-

8
Q

Forodesine

A

Inh of purine nucleoside phosphorylase

Pralatrexate - antifolate

9
Q

Zanolimumab

A

Anti cd4 used in sezary

10
Q

Lennert lymphoma

A

Resembles GA clinically and histo

Rare cd4 systemic lymphoma

11
Q

Plasmacytoma

A

MC seen in myeloma (poor prog), may also be associated with tx, extend from bone, poems, Aesop

Anetoderma may show on bx

MC IG is IgG or A

Spicules in MM composed of Abn monoclonal protein

12
Q

Gingival infiltration

A

AML

13
Q

Congenital leukemia cutis

A

Unlike other lymphomas cutaneous infiltration does not worsen prognosis

May be complicated by linear calcinosis cutis

14
Q

Polycythemia Vera

A

Red skin onthe face neck and acral areas
Engorged bluish mm
Telangectasias, epistaxis, bleeding gums, koilonychia
Aquagenic pruritus usually lasts 30-60 min and independent of water temperature - incr of blood and skin histamine