Magnesium Flashcards Preview

Nutritional Biochem > Magnesium > Flashcards

Flashcards in Magnesium Deck (16)
Loading flashcards...
1

what are the two brush boarder transports (uses Na/ATPase antiport system)

1. transient receptor potential M6 (TRPM6)
2. paracellular diffusion

2

what 4 factors inhibit absorption of magnesium

1. phyates
2. unabsorbed fatty acids that bind to Mg to form soaps
3. phosphorus can form a complex Mg3(Po4)2 within GI
4. zinc competes with Mg absorption

3

PTH function on magnesium

PTH increases Mg absorption only when Mg concentrations are low

4

what are the two transports of magnesium

1. magnesium transport 1 (MagT1) in epithelial cells
2. TRPM7 in bone, heart, and adipose cells

5

kinases: Mg is a ______ for tyrosine kinase

cofactor (required for insulin sensitivity)

6

Mg depletion is common in diabetics due to

excess urinary Mg excretion

7

does Mg supplementation help diabetic patients control disease?

yes

8

5 enzymes that require magnesium

1. transketolase
2. glutamylcysteine synthetase
3. glutathione synthetase
4. DNA polymerase
5. RNA polymerase

9

Mg up regulates the oxidative decarboxylation ____ complex

E1

10

what two transmembrane communication and ion channels are activated by Mg

1. adenylate cyclase
2. Na/K-ATPase pump

11

25-hydroxylase uses Mg as a

cofactor

12

Mg deficiency can ___ calcium plasma concentrations

reduce

13

what 3 ways does Mg act as an antagonist to Ca

1. inhibits release of Ca from sarcoplasmic reticulum
2. competes with Ca for binding sites of troponin
3. inhibits acetylcholine release and smooth muscle contraction *

14

Mg prevents ______ and reduces incidence of myocardial infarction or stoke

hyper coagulability

15

PTH ____ Mg excretion

inhibits

16

____ of US population have dietary Mg intakes less than RDA

70-80%