Malaria Drugs- Regal Flashcards Preview

IHO WEEK 3 > Malaria Drugs- Regal > Flashcards

Flashcards in Malaria Drugs- Regal Deck (7):
1

Choloroquine

binds FRIX, prevents conversion of this toxic substance to hemosin

selectively accumulated in acidic food vacule

Can cause blindness/eye damage

2

Quinine

unknown, possible same at cholorquine

unknown selectivity

Toxicity- cinchonism

3

Quinidine

unknown, possible same as chloroquine

unknown selectivity

Toxicity- cardiac problems

4

Mefloquine

unknown, possible same as chloroquine

unknown selectivity

Toxicity- neuropsychiatric reactions

5

Atovaqone-proguanil

Atovaquone- depolarizes parasites mito and inhibits ETC

Proguanil- inhibits DHFR, selective for plasmodial enzyme

**Not active against hepatic froms

Toxicity- GI distrubances

6

Artemisinins + combo

malarial pigment + drug = free radical that can damage parasite

also inhibits Ca+ATPase in falciparum

Rapid and potent

7

Primaquine

MOA unknown
radical cure! eliminates hepatic forms