Flashcards in MCP - Goodman - FA Synthesis - 2/24 Deck (9)
Where is pyruvate dehydrogenase found?
Only in the mitochondria
Can acetyl-CoA cross the mitochondrial membrane?
No, No, No
From what reaction is NADPH obtained for use in FA synthesis?
breakdown of OAA --> malate --> pyruvate+ NADPH
alternative method: pentose phosphate shunt
What is the rate-limiting/key regulatory enzyme in fatty acid synthesis?
What is the function of fatty acid synthase?
To add 2 carbons to a growing FA chain, resulting eventually in palmitate
What enzymes are responsible for elongating fatty acid chains in the ER?
Elongases, with the normal: reduction-dehydration-reduction method
What are the 3 distinct kinds of desaturases?
common rxns are palmitic to palmitoleic
stearic to oleic (both are monounsaturated, delta9)
What roles do eiconsanoids play?
smooth muscle contraction