MCP - Goodman - FA Synthesis - 2/24 Flashcards Preview

Unit 7 > MCP - Goodman - FA Synthesis - 2/24 > Flashcards

Flashcards in MCP - Goodman - FA Synthesis - 2/24 Deck (9)
Loading flashcards...
1

Where is pyruvate dehydrogenase found?

Only in the mitochondria

2

Can acetyl-CoA cross the mitochondrial membrane?

No, No, No

3

From what reaction is NADPH obtained for use in FA synthesis?

breakdown of OAA --> malate --> pyruvate+ NADPH

alternative method: pentose phosphate shunt

4

What is the rate-limiting/key regulatory enzyme in fatty acid synthesis?

Acetyl-CoA-carboxylase (ACC)

5

What is the function of fatty acid synthase?

To add 2 carbons to a growing FA chain, resulting eventually in palmitate

6

What enzymes are responsible for elongating fatty acid chains in the ER?

Elongases, with the normal: reduction-dehydration-reduction method

7

What are the 3 distinct kinds of desaturases?

delta9
delta6
delta5

common rxns are palmitic to palmitoleic
stearic to oleic (both are monounsaturated, delta9)

8

What roles do eiconsanoids play?

Inflammation
smooth muscle contraction
bronchoconstriction
bronchodilation

9

How do aspirin and NSAIDs work?

They inhibit prostaglandin synthesis at the arachidonic acid --> PGH2 pathway
Aspirin irreversibly inhibits COX-1 and COX-2 (enzymes) whereas acetominophen and ibuprofen are reversible inhibitors.