Flashcards in MCP - Goodman - FA Synthesis - 2/24 Deck (9)
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1
Where is pyruvate dehydrogenase found?
Only in the mitochondria
2
Can acetyl-CoA cross the mitochondrial membrane?
No, No, No
3
From what reaction is NADPH obtained for use in FA synthesis?
breakdown of OAA --> malate --> pyruvate+ NADPH
alternative method: pentose phosphate shunt
4
What is the rate-limiting/key regulatory enzyme in fatty acid synthesis?
Acetyl-CoA-carboxylase (ACC)
5
What is the function of fatty acid synthase?
To add 2 carbons to a growing FA chain, resulting eventually in palmitate
6
What enzymes are responsible for elongating fatty acid chains in the ER?
Elongases, with the normal: reduction-dehydration-reduction method
7
What are the 3 distinct kinds of desaturases?
delta9
delta6
delta5
common rxns are palmitic to palmitoleic
stearic to oleic (both are monounsaturated, delta9)
8
What roles do eiconsanoids play?
Inflammation
smooth muscle contraction
bronchoconstriction
bronchodilation
9
