MEH - Intro To Endocrinology Flashcards Preview

CJ: UoL Medicine Semester Two (ESA2) > MEH - Intro To Endocrinology > Flashcards

Flashcards in MEH - Intro To Endocrinology Deck (40)
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31

Where is the appetite control centre located?

In the hypothalamus

32

What is the appetite control centre composed of?

Clusters of neurones called 'nuclei' which make up the arcuate nucleus

33

What are the two types of primary neurone in the arcuate nucleus?

- stimulatory neurones, which contain neuropeptide Y (NPY) and Agoouti-related peptide (AgRP) and promote hunger
- inhibitory neurones, which contain pro-opiomelanocortin (POMC) which yields several neurotransmitters, including alpha-MSH and beta-endorphin and promote satiety

34

What do primary neurones synapse with?

Secondary neurones in other regions of the hypothalamus, and the signals are integrated to alter feeding behaviour

35

What is leptin released by?

Released into blood by adipocytes

36

How does leptin suppress appetite?

- stimulates inhibitory (POMC) neurones
- inhibits excitatory (AgRP/NPY) neurones in the arcuate nucleus
- induces expression of uncoupling proteins in mitochondria, so energy is dissipated as heat

37

What is the role of insulin in appetite regulation?

It suppresses appetite by similar mechanism as leptin

38

Where is amylin released from?

Peptide hormone secreted by beta cells in the pancreas

39

What are the roles of amylin?

Role not fully understood, but definitely suppresses appetite, decreases glucagon secretion and slows gastric emptying

40

What is pramlintide?

An amylin analogue approved for treatment of type 2 diabetes

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