melanoma Flashcards

0
Q

melanoma in situ

A

confined to epidermis
well defined
sun or nonsun exposed

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1
Q

risk factors of melanoma

A
UV
fair skin
genetics: CDKN2A mutation
nevi
xeroderma pigmentosum
immunosuppression
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2
Q

lentigo maligna

A

confined to epidermis
sun exposed skin
illdefined

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3
Q

main place in females

A

back of legs

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4
Q

main palce in men

A

on trunk

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5
Q

lentigo maligna

A

70s, sun damaged skin

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6
Q

acral lentingous

A

dark skin >light skin
50s and 60s
hands and feet digits

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7
Q

amelanotic

A

red color in forgotten melanoma locations-periungual, mucosal, genital, oral, anal-rectal, urethra, eso, ocular

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8
Q

pediatric melanoma

A

3% of pediatric cancers; 90% occur between ages 10-19

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9
Q

children with congenital melanocytic nevi

A

have a 465 fold increased risk of developing melanoma in childhood and adolescence
scalp and neck are most common sites

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10
Q

px dependent on site

A

best to worst

extremities>head neck trunk? volar or sublingual

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11
Q

ulceration

A

worst prognosis

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12
Q

breslow thickness

A

measured from top of granular cell layer to deepest point of tumor penetration

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13
Q

lymph nodes

A

number and burden

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14
Q

site of distant mets

A

worst with visceral vs just skin

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15
Q

t classification a

A

w/o ulceration

16
Q

t calssification b

A

w/ ulceration

17
Q

stage 1-2 a

A

excision

18
Q

stage 2b-2c

A

excision + interferon

19
Q

stage 3

A

WLE + trial or IFNa or observation

20
Q

stage 4

A

new and changing

21
Q

iplimumab

A

+ t cells, not effective, but buys you some time

22
Q

vermurfenib

A

gives you a 20% increased survival rate