Membranous Nephropathy Flashcards Preview

Nelson - Nephrology > Membranous Nephropathy > Flashcards

Flashcards in Membranous Nephropathy Deck (14):
1

T/F Membranous nephropathy is a common cause of nephrotic syndrome in children

F, rare cause

2

T/F In children, secondary MN is far more common than primary MN

True

3

MC etiologies of secondary MN

1) SLE 2) Chronic infections

4

Best characterized and recognized causes of MN among the chronic infections

1) Hepatitis B 2) Congenital syphilis

5

T/F In MN, removal of offending agent or treatment of the causative disease often leads to resolution of associated nephropathy

T

6

Pathology of MN

Diffuse thickening of GBM WITHOUT significant cell proliferative changes

7

GBM thickening in MN presumably results from

Production of membrane-like material in response to deposition of immune complexes

8

T/F MN is believed to be caused by in situ immune complex formation

T

9

MN is MC at what age group

2nd decade of life

10

MN usually manifests as nephritic vs nephrotic syndrome

Nephrotic syndrome

11

Approximately ___% of children with MN have hypertension at presentation

20%

12

This well known complication of nephrotic syndrome is particularly common in patients with MN

Renal vein thrombosis

13

T/F Diagnosis of MN can only be established by renal biopsy

T

14

___% of children with MN progress to renal failure, ___% continue with active disease, and ___% achieve complete remission

20%, 40%, 40%