Metastatic melanoma Flashcards

1
Q

What diagnostic test?

A

FULL thickness excisional biopsy!

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2
Q

What are safety margins for melanoma?

A
Early stage (I and II): 1 cm
Late stage (III and IV): 2 cm
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3
Q

MOST important prognostic factor?

A

Thickness

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4
Q

How to classify thickness?

A

Breslow scale

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5
Q

Common metastases?

A
Skin
Lymphoma
Lung
Brain
Liver
Bones
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6
Q

MC cytotoxic drug?

A

Dacarbazine

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7
Q

Side effects of dacarbazine?

A

N/V, leukopeniam thrombocytopenia, anemia

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8
Q

Modern drugs?

A

Ipilimumab
Nivolumab
Vemurafenib
Trametinib

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9
Q

Mechanism of ipilimumab?

A

CTLA-4 inhibitor = activates T cells

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10
Q

Side effect of Ipilimumab?

A
Skin toxicity (rash)
 \+ severe adverse reactions
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11
Q

Mechanism of nevolumab?

A

PD-1 inhibitor = blocks program death

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12
Q

Side effect of nevolumab?

A

Skin toxicity

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13
Q

Mechanism of Vemurafenib?

A

BRAF inhibitors

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14
Q

Sideeffects of Vemurafenib?

A

Skin toxicity

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15
Q

Mechanism of Trametinib?

A

MEK inhibitor

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16
Q

Side effect of trametinib?

A

Skin toxicity