MICRO - Antimycobacterial drugs Flashcards Preview

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Flashcards in MICRO - Antimycobacterial drugs Deck (16)
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1
Q

Isoniazid - MOA

A

Decrease synthesis of mycolic acid

2
Q

Isoniazid - Use

A

MTB prophylaxis and treatment

3
Q

Isoniazid - activation

A

KatG –> Catalase-peroxidase –> active metabolite

4
Q

Isoniazid - AE

A

Lupus like symptoms Decreased B6 –> Neurotoxicity, sideroblastic anemia

5
Q

Ethambutol - MOA

A

Blocks arabinosyl transferase –> decreased cell wall

6
Q

Ehtambutol - AE

A

Red green color blindness (optic neuropathy)

7
Q

Rifampin, Rifambutin - MOA

A

DNA - Dependent RNA polymerase inhibition

8
Q

Rifampin, rifambutin - AE

A

Orange fluids

9
Q

Rifampin - AE

A

Orange fluids + CYP450 induction

10
Q

Ethambutol - Treats

A

MTB treatment

11
Q

Rifampin, rifambutin - Treats?

A

MTB treatment Mycobacterium leprae treatment H. influenza type B and meningococcal exposure prophylaxis

12
Q

Pyrazinamide - Treats

A

MTB treat

13
Q

Pyrazinamide - AE

A

Hyperuricemia

14
Q

M. Tuberculosis: Prophylaxis and Rx

A

Prophylaxis = INH

Rx = RIPE (rifampin/rifambutin, INH, Pyrazinamide, Ethambutol)

15
Q

MAC: prophylaxis and Rx

A

Prophylaxis = Azithromycin + rifambutin

Rx = Azithromycin Or Clarithromycin; + ethambutol. [can add rifambutin or cipro]

16
Q

M. leprae: Prophylaxis; tuberculoid Rx; lepromatous Rx

A

Prophylaxis = N/A!!!

Tuberculous = dapsone + rifampin

Lepromatous = dapsone + rifampin + clofazimine