Micro Pharm II

Question 1

TMP/SMX MOA

Answer 1

• SMX: Folic acid synthesis inhibitor
• TMP: Folic Acid utilization inhibitor
• cial (notes say static)

Question 2

TMP/SMX Agent Fate excretion

Answer 2

Oral, parenteral (except Pneumosystis jaroveci), renal

Question 3

TMP/SMX ADR

Answer 3

-Blood dyscrasias, Steven Johnson Syndrome, —–Kenicterus (Contra indicated in Newborns)

Question 4

TMP/SMX DI

Answer 4

-WARFARIN (increases warfarin levels, increases bleed risk)

Question 5

Vancomycin MOA

Answer 5

• cell wall, cytoplasm membrane, slow acting

- cidal

Question 6

Vancomycin Agent fate excretion

Answer 6

-oral (C diff), IV, RENAL EXCRETION, trough levels

Question 7

Vancomycin ADR

Answer 7

-Nerphro, oto, RED NECK (when given too rapidly)

Question 8

Vancomycin DI

Answer 8

Other similar adrs (ampho, gent, loop diuretics)

Question 9

Macrolides (azithromycin, clarithromycin, erythromycine) MOA

Answer 9

-50s subunit

Question 10

Macrolides (azithromycin, clarithromycin, erythromycine) Agent fate excretion

Answer 10

-oral, parenternal, METABOLIZED VIA CYP 3A4

Question 11

Macrolides (azithromycin, clarithromycin, erythromycine) ADR

Answer 11

-N/V

Question 12

Macrolides (azithromycin, clarithromycin, erythromycine) DI

Answer 12

-INTERFERE WITH CYP 3A4 (many drug interactions)

Question 13

Cipro: When not used/when to use

Answer 13

• Not used for MRSA
• Used for P aeruginosa
• Good bone penetration, wide spectrum

Question 14

Clindomyocin MOA

Answer 14

-50s, -static

Question 15

Clindomyocin Agent Fate Excretion

Answer 15

-Oral, parenteral, active tubular, PROTEIN BOUND, metabolism, BILE, URINE

Question 16

Clindomyocin ADR

Answer 16

-C. DIFF, diarrhea

Question 17

Clindomyocin DI

Answer 17

-50s