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Flashcards in MOD Self-assessment question Deck (224)
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1

Infarcts seen in the spleen are usually haemorrhagic? (T/F)

False - they are typically pale infarcts

2

Infarcts in the lungs are usually haemorrhagic? (T/F)

True

3

Infarcts in the brain heal by gliosis? (T/F)

True - gliosis is the main reparative mechanism of the CNS

4

Infarcts usually result from ischaemia? (T/F)

True

5

Infarcts are a manifestation of apoptosis? (T/F)

False - Infarcts represent the deaths of many cells. Apoptosis is the programmed cell death of a single or small collection of cells.

6

Free-radicals damage cells by cross-linking proteins? (T/F)

True

7

Free radicals damage cells by breaking strands of DNA? (T/F)

True

8

Free radicals damage cells by oxidising membrane lipids? (T/F)

True - this is an important mechanism of membrane damage.

9

Free radicals damage cells by activating cell surface receptors? (T/F)

False - there are no specific cell or cytoplasmic receptors for free radicals

10

Free radicals damage cells by activating cytoplasmic receptors? (T/F)

False

11

Apoptosis is involved in limb modelling in embryogenesis? (T/F)

True - selective cell death is an important process in embryogenesis.

12

Apoptosis is a frequent result of ischaemic injury? (T/F)

False - necrosis not apoptosis follows ischaemia.

13

Apoptosis is a physiological process? (T/F)

True.

14

Apoptosis involves active transcription of genes? (T/F)

True - apoptosis is an active process.

15

Apoptosis is seen in the liver in hepatitis? (T/F)

True

16

In reversible cell injury due to oxygen deprivation, ATP levels fall? (T/F)

True - reduced oxidative phosphorylation leads to a reduction in ATP.

17

In reversible cell injury due to oxygen deprivation, ribosomes are detached form the ER? (T/F)

True

18

In reversible cell injury due to oxygen deprivation, pyknosis occurs? (T/F)

False - pyknosis is a feature of irreversible cell injury. Clumped chromatin is seen in reversible oncosis BUT pyknosis is CONDENSED chromatin and is IRREVERSIBLE.

19

In reversible cell injury due to oxygen deprivation, mitochondria swell? (T/F)

True

20

In reversible cell injury due to oxygen deprivation, there is lysosomal disruption (T/F)?

False - that is a feature of irreversible cell injury

21

Would myocardium undergo irreversible cell injury within 60 minutes of complete cessation of blood supply (Y/N)?

Yes

22

Would motor neurones undergo irreversible cell injury within 60 minutes of complete cessation of blood supply (Y/N)?

Yes

23

Would skeletal muscle undergo irreversible cell injury within 60 minutes of complete cessation of blood supply (Y/N)?

No

24

Would renal tubules undergo irreversible cell injury within 60 minutes of complete cessation of blood supply (Y/N)?

Yes

25

Would chondrocytes undergo irreversible cell injury within 60 minutes of complete cessation of blood supply (Y/N)?

No

26

Neutrophil polymorphs have multiple nuclei (T/F)?

False - they have single polylobulated nuclei

27

Neutrophil polymorphs are the major cell type of acute inflammation (T/F)?

True

28

Neutrophil polymorphs fuse to form giant cells (T/F)?

False - macroophages fuse to form giant cells.

29

Neutrophil polymorphs have are phagocytic (T/F)?

True - they may phagocytose and kill bacteria.

30

Neutrophil polymorphs generate hydrogen peroxide (T/F)?

True - hydrogen peroxide is used by myeloperoxidase enzyme to form HOCL. (hypochlorite) in order to effect bacterial killing.