Flashcards in MOD Session 5- Haemostasis And Thrombosis Deck (21)
The body's response to prevent blood loss and stop bleeding
What is the key step in the coagulation cascade?
What is the main step in the fibrinolytic system?
Plasminogen=> plasmin via plasminogen activators
Plasmin breaks down fibrin.
2 examples of fibrinolytic therapies
Why is streptokinase a fibrinolytic therapy?
It activates plasminogen.
The formation of a solid mass of blood within he circulatory system.
What is Virchow's triad?
States that Thrombosis occurs due to:
- vessel wall abnormalities
- blood flow abnormalities
- blood component abnormalities
Give an example of a blood vessel wall abnormality
Atheroma, direct injury, inflammation
Given an example of a blood flow abnormality
Give an example of why a blood component abnormality arises
Smokers, post-op, pregnancy
The blockage of a blood vessel by a solid, liquid or gas, at a site distant from its site of origin.
What are the 5 types of emboli?
What are the predisposing factors of DVT? (7)
-trauma and severe burns
Why is a massive pulmonary embolism (PE) rapidly fatal?
Causes more than 60% blood flow reduction.
What is given to prevent DVT?
What is the treatment for DVT?
What are the four necessary components for successful haemostasis?
-constriction of blood vessels in the vessel wall
-platelets adhere to each other and the damaged vessel wall to form a plug.
-coagulation system- cascade that converts prothrombin to thrombin, which in turn converts fibrinogen to fibrin.
-fibrinolytic system- activates plasmin through conversion of plasminogen to plasmin, is in turn causes the break down of fibrin.
Give two examples of thrombin inhibitors. What happens if you have a deficiency in them?
Anti thrombin III
Thrombosis of thrombophilia can result.
Describe the appearance of a venous thrombus. (3)
Dark red, soft and has a high cell content
Describe the appearance of an arterial thrombus. (3)
Pale, granular and has a low cell content.