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Flashcards in Molecular biology Deck (11)
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1
Q

Herceptin (Trastuzumab)

A

Humanised monoclonal antibody. Binds and blocks HER2. Originally licensed for final stage HER2+ cancer but now available to early stage pts.

2
Q

Drugs Herceptin is usually given with

A

Doxorubicin, cyclophosphamide, paclitaxel.

3
Q

Pertuzumab

A

Inhibits receptor dimerisation.

4
Q

Advexin

A

Adenoviral transfer of p53 into tumour cells. Head and neck cancers

5
Q

CDB3/PRIMA-1

A

Stabilises mutant p53 and restores transcriptional function.

6
Q

Pifithrin

A

Supreses endogenous p53 in normal tissue to reduce susceptibility to chemotherapy/radiation induce apoptosis.

7
Q

Avastin (Bevacizumab)

A

Humanised monoclonal antibody - anti-VEGFA. Given in cominbtation with 5-FU or Leucovorin or other kinase inhibitors.

8
Q

Dasatinib and nilotinib

A

2nd generation CML treatment. Bind active conformation of BCR-Abl. Ineffective against T315I mutation.

9
Q

JAK2 inhibitor

A

3rd generation CML treatment. Withdrawn from trials due to cardiotoxicity

10
Q

MEK inhibitor

A

C1-1040 (phase 1 trials for colon cancer)

11
Q

Raf inhibitor

A

Nexavar (sorafenib) approved for renal carcinoma, also binds VEGFR and PDGFR