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Nelson - Nephrology > MPGN > Flashcards

Flashcards in MPGN Deck (19)
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1
Q

MPGN is aka

A

Mesangiocapillary GN

2
Q

MPGN is associated with infected shunts especially what kind of shunts

A

Ventriculoatrial shunts (shunt nephritis)

3
Q

What type of MPGN is most common

A

Type I

4
Q

___ when seen on histology, indicate a poor prognosis for MPGN

A

Crescents

5
Q

Differentiation between Type I and II MPGN is done via

A

IF and EM

6
Q

IF finding in Type I vs Type II MPGN

A

Type I: C3 and less Ig, Type II: C3 without Ig

7
Q

EM finding in Type I vs Type II MPGN

A

Type I: Numerous deposits in the mesangial and subendothelial regions, Type II: Very dense lamina densa in GBM without evident immune complex-type deposits

8
Q

Occurs when circulating immune complexes become trapped in the glomerular subendothelial space

A

Type I MPGN

9
Q

T/F Type II MPGN, like Type I, is mediated by IC deposition

A

F

10
Q

Typical lab finding in Type II MPGN

A

Depressed C3 with normal levels of other complement components

11
Q

MPGN associated with the presence of C3 nephritic factor

A

Type II MPGN

12
Q

Systemic disease associated with Type II MPGN where there is diffuse loss of adipose tissue and decreased complement

A

Partial lipodistrophy

13
Q

MPGN is most common in what age group

A

2nd decade of life

14
Q

T/F Treatment of causative disease can result in resolution of MPGN

A

T

15
Q

Patients with MPGN who have ___ at the time of presentation progress to renal failure more rapidly

A

Nephrotic syndrome

16
Q

C3 level, MPGN vs PSGN

A

MPGN: C3 levels usually remain persistently low; PSGN: C3 levels return to normal within 2 months after onset

17
Q

Indications for renal biopsy in MPGN

A

1) Nephrotic syndrome in an older child 2) Significant proteinuria with microscopic hematuria 3) Hypocomplementemia lasting >2 months in a child with acute nephritis

18
Q

T/F Untreated idiopathic MPGN, regardless of type, has a poor prognosis

A

T

19
Q

By ___ years after onset, 50% of patients with MPGN have progressed to ESRD

A

10