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Nelson - Nephrology > MPGN > Flashcards

Flashcards in MPGN Deck (19):
1

MPGN is aka

Mesangiocapillary GN

2

MPGN is associated with infected shunts especially what kind of shunts

Ventriculoatrial shunts (shunt nephritis)

3

What type of MPGN is most common

Type I

4

___ when seen on histology, indicate a poor prognosis for MPGN

Crescents

5

Differentiation between Type I and II MPGN is done via

IF and EM

6

IF finding in Type I vs Type II MPGN

Type I: C3 and less Ig, Type II: C3 without Ig

7

EM finding in Type I vs Type II MPGN

Type I: Numerous deposits in the mesangial and subendothelial regions, Type II: Very dense lamina densa in GBM without evident immune complex-type deposits

8

Occurs when circulating immune complexes become trapped in the glomerular subendothelial space

Type I MPGN

9

T/F Type II MPGN, like Type I, is mediated by IC deposition

F

10

Typical lab finding in Type II MPGN

Depressed C3 with normal levels of other complement components

11

MPGN associated with the presence of C3 nephritic factor

Type II MPGN

12

Systemic disease associated with Type II MPGN where there is diffuse loss of adipose tissue and decreased complement

Partial lipodistrophy

13

MPGN is most common in what age group

2nd decade of life

14

T/F Treatment of causative disease can result in resolution of MPGN

T

15

Patients with MPGN who have ___ at the time of presentation progress to renal failure more rapidly

Nephrotic syndrome

16

C3 level, MPGN vs PSGN

MPGN: C3 levels usually remain persistently low; PSGN: C3 levels return to normal within 2 months after onset

17

Indications for renal biopsy in MPGN

1) Nephrotic syndrome in an older child 2) Significant proteinuria with microscopic hematuria 3) Hypocomplementemia lasting >2 months in a child with acute nephritis

18

T/F Untreated idiopathic MPGN, regardless of type, has a poor prognosis

T

19

By ___ years after onset, 50% of patients with MPGN have progressed to ESRD

10