Glatiramer Acetate: class
Glatiramir
Glatiramer Acetate: MOA
Decreases activation of T cells;
Activates Th2 cells
Glatiramer Acetate: indication
RRMS
Glatiramer Acetate: side effect
Chest tightness, dyspnea
Glatiramer Acetate: Route of admin
IM
Glatiramer Acetate reduces relapses by ____ per year
28%
Interferon B-1a: class
Beta Interferon
Interferon B-1a: MOA
Decreases Tcell activation
Promotes Th2 cells
Decreases microglial proliferation
Interferon B-1a: indication
RRMS
Interferon B-1a: side effect
flu-like sxs (60%)
Interferon B-1a: contraindication
Allergy to E.coli - derived products
What can happen after 18-24 months on Interferon B-1a?
Development of neutralizing Abs
Fingolimod: class
S1P receptor modulator
Fingolimod: MOA
Acts to keep T cells in lymphoid tissue
Fingolimod: indication
Relapsing forms of MS
Fingolimod: side efects
Bradycardia
Fingolimod: contraindications
Lack of VZV immunity
Fingolimod decreases circulating lymphoctes by ____ for up to _____ after it’s discontinued.
75%
2 months
Natalizumab: class
Selective Adhesion-Molecule Inhibitor
Natalizumab: MOA
Prevents lymphocyte migration into CNS
Natalizumab: indication
Relapsing forms of MS
Natalizumab: side efects
Progressive multifocal enecphalopathy
Access of Natalizumab is restricted to whom?
TOUCH program participants
Dimethyl Fumarate: class
Nrf2 Activator
Dimethyl Fumarate: MOA
Unknown - but thought to arise from activation of anti-oxidative pathways
Dimethyl Fumarate: indication
RRMS
Dimethyl Fumarate: side effect
Progressive multifocal encephalopathy
Dimethyl Fumarate: pregnancy class
Unknown - too new
Dimethyl Fumarate reduces relapses by ___ per year
75%
Baclofen: class
Antispasmotic
Baclofen: MOA
GABA receptor agonist producing hyperpolarization and pre-synaptic inhibition
Baclofen: indication
Muscle spasticity in MS and spinal cord lesions
If you want to D/C Baclofen, how do you do it?
Down titrate slowly
Dantrolene: class
Antispasmotic
Dantrolene: MOA
Blocks RyR1 Ca++ channels in sarcoplasmic reticulum, esp rapid contraction fibers
Dantrolene: indication
Upper motor neuron spasticity