Muscle and Nerve Disease Flashcards Preview

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Flashcards in Muscle and Nerve Disease Deck (21)
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1

What are the general symptoms of muscle disease?

Weakness of skeletal muscle
Dyspnoea
Cardiomyopathy
Cramp, pain
Myoglobinuria
Poor feeding

2

What are the general signs of muscle disease?

Wasting/ hypertrophy
Abnormal tone and reflexes
Motor weakness

3

What are the investigations for muscle disease?

CK
EMG
Muscle biopsy
Genetic testing

4

What are the classifications of muscle disease?

Muscular dystrophies
Channelopathies
Metabolic muscle disease
Inflammatory muscle disease
Congenital myopathies

5

What are the different types of muscular dystrophy?

Duchenne's
Becker's
Limb-Girdle
Myotonic
Facioscpulohumeral

6

What is a channelopathy?

Disorder of Ca, Na and Cl channels

7

What are the different types of channelopathies?

Familial hyopkalemic periodic paralysis
Hyperkalemic periodic paralysis
Paramyotonia congenita
Myotinia congenita

8

What is metabolic muscle disease?

Disorders of carbohydrate and lipid metabolism

9

What are the types of inflammatory muscle disease?

Polyyositis
Dermatomyositis

10

What are the investigations for inflammatory muscle disease?

EMG
Increased CK
Biopsy (PM-CD8 cells, DM-B cells, CD4 cells)

11

What is the treatment for inflammatory muscle disease?

Immunosuppression

12

What is the clinical presentation of a neuromuscular junction disorder?

Fatiguable weakness of limbs, muscles of mastication, talking
Diplopia
Dyspnoea
Ptosis

13

What are the investigations for neuromuscular junction disorders?

AChR ab
Anti MuSK ab
Neurophysiology
Tensilon test
CT chest

14

What is the treatment for neuromuscular junction disorder?

Acetylcholinesterase inhibitor
Prednisolone
Steroid saving agent (azathioprine)

15

What is affected in peripheral nerve disorder?

Sensory axons (small and large fibres)
Motor axons
Autonomic nervous system

16

What is the cause of generalised peripheral neuropathy?

Drugs
Herditary
Lyme, HIV, leprosy
Paraneoplastic malignancy
Guillain Barre syndrome

17

What are the signs and symptoms of nerve disease?

Myotomal wasting and weakness
Reflex change
Dermatomal sensory change

18

What are the investigations for nerve disease?

Bloods
Genetic analysis
NCS
Lumbar puncture (CSF analysis)
Nerve biopsy

19

What is ALS?

Amyotrophic lateral sclerosis

20

What are the features of motor neuron disease?

Combination of UMN and LMN
Muscle fasciculations, wasting, weakness
Increased tone, brisk reflexes
No sensory involvement

21

What is the treatment for motor neuron disease?

PEG, NIV (supportive)
Riluzole