Flashcards in Muscle and Nerve Disease Deck (21)
What are the general symptoms of muscle disease?
Weakness of skeletal muscle
What are the general signs of muscle disease?
Abnormal tone and reflexes
What are the investigations for muscle disease?
What are the classifications of muscle disease?
Metabolic muscle disease
Inflammatory muscle disease
What are the different types of muscular dystrophy?
What is a channelopathy?
Disorder of Ca, Na and Cl channels
What are the different types of channelopathies?
Familial hyopkalemic periodic paralysis
Hyperkalemic periodic paralysis
What is metabolic muscle disease?
Disorders of carbohydrate and lipid metabolism
What are the types of inflammatory muscle disease?
What are the investigations for inflammatory muscle disease?
Biopsy (PM-CD8 cells, DM-B cells, CD4 cells)
What is the treatment for inflammatory muscle disease?
What is the clinical presentation of a neuromuscular junction disorder?
Fatiguable weakness of limbs, muscles of mastication, talking
What are the investigations for neuromuscular junction disorders?
Anti MuSK ab
What is the treatment for neuromuscular junction disorder?
Steroid saving agent (azathioprine)
What is affected in peripheral nerve disorder?
Sensory axons (small and large fibres)
Autonomic nervous system
What is the cause of generalised peripheral neuropathy?
Lyme, HIV, leprosy
Guillain Barre syndrome
What are the signs and symptoms of nerve disease?
Myotomal wasting and weakness
Dermatomal sensory change
What are the investigations for nerve disease?
Lumbar puncture (CSF analysis)
What is ALS?
Amyotrophic lateral sclerosis
What are the features of motor neuron disease?
Combination of UMN and LMN
Muscle fasciculations, wasting, weakness
Increased tone, brisk reflexes
No sensory involvement