Muthu skin cancer Flashcards Preview

Dermatology > Muthu skin cancer > Flashcards

Flashcards in Muthu skin cancer Deck (19)
Loading flashcards...
1
Q

Which professions more likely to get SCC?

A

SCC: >90% on head, neck, hands, forearms

Outdoor workers, farmers, sailors, recreational

2
Q

Childhood sunburn increases melanoma risk by what

A

4 fold

3
Q

Sunscreen reduces which type of cancer?

A

SCC (not BCC)

4
Q

Phototoxic drugs

A
Psoralen
Voriconazole
Vemurafenib
Azathioprine
Thiazide diuretics
Anti-TNF
NSAIDS
BRAF inhibitors
5
Q

Environmental carcinogens

A
Coal tar
Smoking
Ionising radiation
Arsenic
Trauma
Chronic ulceration
6
Q

Aside from the obvious skin conditions, what other diseases predispose to cancer?

A

Ankylosing spondylitis
Scalp ringworm
Previous skin cancer

(HPV infection)

7
Q

What percentage of sunburn occurs in the first 18 years of life?

A

Up to 80%

8
Q

Gorlin’s syndrome

A

Naevoid basal cell carcinoma

9
Q

Naevoid basal cell carcinom

A

Gorlin syndrome

10
Q
photosensitivity  
 skin cancers on UV-exposed sites
 neurological degeneration
 Increased risk of other cancers
 Defect in one of seven Nucleotide 
Excision Repair (NER) genes (XPA - G)
A

Xeroderma pigmentosum

11
Q

Which type of gene is affected in xeroderma pigmentosum?

A

Nucleotide excision repair gene (XPA-G)

12
Q

Median age for cancer onset in xeroderma pigmentosum?

A

Age 8

13
Q

Gorlin’s syndrome inheritance?

A

Autosomal dominant

14
Q

Features of Gorlin’s syndrome

A
  • early onset/multiple BCCs
  • jaw cysts
  • palmar pits
  • ectopic calcification falx cerebri

(Minor features: skeletal abnormality, OFC >97th centile, cardia/ovarian fibroma, medulloblastoma)

15
Q

Hereditary type VII collagen deficiency

A

Recessive epidermolysis bullosa

high risk patients

16
Q

Where might you get field cancerisation after having a transplant?

A
The hands
(field change = accelerated progression to SCC)
17
Q

Why do organ donor recipients need regular skin surveillance?

A

Rapid progression from AK to SCC

18
Q

What type of suncream should you use?

A

Broad spectrum (SPF25+) with UVA protection

19
Q

Average application of suncream?

A
  • average application is only 1/3rd of SPF you need
  • most don’t apply enough
  • most don’t reapply it properly