Nelson - Ch. 197 Pertussis Flashcards
T/F In pertussis, most individuals do not whoop
T
T/F Neither natural disease nor vaccination provides complete or life-long immunity against pertussis reinfection or disease
T
Bordetella organisms are small, fastidious, G- coccobacilli that colonize only ___ epithelium
Ciliated
Among Bordetella species, only B pertussis expresses ___, the major virulence protein
Pertussis toxin
3 B pertussis components that are important for attachment to ciliated respiratory epithelial cells
Filamentous hemagglutinin, some agglutinogens, and pertactin
3 B pertussis components that appear to inhibit clearance of organisms
1) Tracheal cytotoxin 2) Adenylate cyclase 3) PT
3 B pertussis components that are postulated to be predominantly responsible for the local epithelial damage that produces respiratory symptoms that facilitates absorption of PT
1) Tracheal cytotoxin 2) Dermonectrotic factor 3) Adenylate cyclase
T/F Chronic carriage of B pertussis by humans is documented
F
Pertussis is extremely contagious with attack rates as high as ___ in susceptible individuals exposed to aerosol droplets at close range
100%
After intense exposure to B pertussis, as in household contacts, rate of subclinical infection is as high as ___ in fully immunized or previously infected individuals
80%
Stages of pertussis
1) Catarrhal (1-2wks) 2) Paroxysmal stage (2-6wks) 3) Convalescent stage (≥2 weeks)
Incubation period of pertussis
3-12 days
Hallmark of pertussis
Inexorable paroxysms of cough
T/F In pertussis, posttusive emesis is common and exhaustion is universal
T
Pertussis stage: Nondistinctive symptoms
Catarrhal
