Nelson - Ch. 200 E. coli Flashcards

1
Q

E.coli ?aerobic ?gram ?lactose

A

Facultative anaerobic, G-, lactose fermenter

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2
Q

T/F Most fecal E.coli cause diarrhea

A

F, do not cause

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3
Q

Most diarrheagenic E.coli except ___ require a large inoculum of organisms to induce disease

A

STEC

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4
Q

MCC of traveler’s diarrhea

A

ETEC

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5
Q

Accounts for 10-30% of dehydrating infantile diarrhea

A

ETEC

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6
Q

Enterotoxin produced by ETEC associated with increased risk of death

A

ST-ETEC or heat stable enterotoxin

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7
Q

ETEC diarrhea is self-limited and resolves in

A

3-5 days, occasionally longer than 1 week

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8
Q

ETEC enterotoxin that is structurally, functionally, and immunologically related to cholera toxin produced by V. cholerae

A

LT or heat labile toxin

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9
Q

ETEC enterotoxin: Large molecule

A

LT

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10
Q

ETEC enterotoxin: Small molecule

A

ST

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11
Q

ETEC enterotoxin: Stimulates adenylate cyclase –> increased CAMP

A

LT

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12
Q

ETEC enterotoxin: Stimulates guanylate cyclase –> increased CGMP

A

ST

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13
Q

Genes for ST and LT of ETEC are encoded on

A

Plasmids

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14
Q

E. coli: Explosive, nonmucoid, nonbloody diarrhea, little or no fever

A

ETEC

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15
Q

E. coli: Resembles bacillary dysentery since it shares virulence genes with Shigella spp

A

EIEC

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16
Q

E. coli: Cause colonic ulcerations, hemorrhage, mucosal and submucosal edema, and infiltration by PMNs

A

EIEC

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17
Q

E. coli: Nonmotile and usually non lactose fermenting

A

EIEC

18
Q

E. coli: Acute, prolonged (>7d), and persistent diarrhea (>14) in children less than 2

A

EPEC

19
Q

E. coli: Outbreaks in daycare centers

A

EPEC

20
Q

E. coli: Studies show that breastfeeding is protective against diarrhea caused by

A

EPEC

21
Q

E. coli: Duodenum through colon

A

EPEC

22
Q

E. coli: Colonization causes blunting of villi, inflammatory changes, and sloughing of superficial mucosal cells

A

EPEC

23
Q

E. coli: Characteristic attaching and effacing histopathologic lesion

A

EPEC

24
Q

E. coli: Abdominal pain with diarrhea that is initially watery but within a few days become blood-streaked or grossly bloody

A

STEC

25
Q

Associated with HUS

A

STEC

26
Q

Severe illness with STEC occurs in what age-group

A

6m-10yrs

27
Q

STEC-positive young children with ___ early in the course of diarrhea are at high risk for HUS progression

A

Bloody diarrhea and neutrophilic leukocytosis

28
Q

Poorly cooked hamburger, apple cider, mayonnaise, spinach, dry fermented sausage, unpasteurized dairy

A

STEC

29
Q

STEC affects the ___ most severely

A

Colon

30
Q

Attaching-effacing lesions like those seen in EPEC but with production of toxins that kill cells

A

STEC

31
Q

Key virulence factors of STEC

A

Shiga toxins aka VEro toxins aka Shiga like toxins

32
Q

The ___ family of toxins produced by STEC is associated with a higher risk of causing HUS

A

Stx2

33
Q

MC STEC serotype

A

O157:H7, O111:NM and O26:H11

34
Q

Most virulent STEC serotype

A

O157:H7

35
Q

E coli most frequently associated with HUS

A

O157:H7

36
Q

2nd MCC of traveler’s diarrhea

A

EAEC

37
Q

Acute and persistent diarrhea in HIV-infected adults and children

A

EAEC

38
Q

Associated with growth retardation and malnutrition in infants

A

EAEC

39
Q

Form a characteristic biofilm on the intestinal mucosa and induce shortening of the villi

A

EAEC

40
Q

Secretory mucoid diarrhea

A

EAEC

41
Q

AA fimbriae

A

EAEC