Neruo 11.2 Dementia Flashcards Preview

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Flashcards in Neruo 11.2 Dementia Deck (10):
1

Define dementia

progressive decline of cognitive function (impairment of intellect, reason and personality without impairment of consciousness), usually affecting the cortex as a whole (though can sometimes be patchy)

2

What are the most common causes of dementia?

AD, dementia with lewy bodies, vascular dementia

3

Describe the symptoms of AD

progressive memory loss, aphasia, apraxia, agnosia, depression, behavioural changes

4

What is pathophysiology of AD?

Neurofibrillary tangles - Twisted filaments of tau protein. Tau stabilises microtubules in cell. Senile plaques - amyloid deposition of aBeta protein.

5

Symptoms of lewy body dementia?

Fluctuating cognition. More rapid symptoms than AD.

6

What causes vascular dementia

multiple infarcs in cortex.

7

What is frontotemporal dementia?

Atrophy of frontal and temporal lobes

8

What are subcortical encephalopathies

Disorders that affect subcortical structures e.g. huntingtons disease and parkinsons

9

What are primary progressive aphasia?

language based dementia

10

How is dementia diagnosed? What is seen on MRI in AD?

History and cognitive testing. MRI - bilateral atrophy of hippocampus in AD.