Neuroblastoma Flashcards Preview

CP2 - Paediatric Oncology > Neuroblastoma > Flashcards

Flashcards in Neuroblastoma Deck (3)
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1
Q

What is the system of origin in a neuroblastoma?

A

A solid tumour developing from the developing sympathetic nervous system.

It is an embryonal neoplasm and therefore is seen in early childhood.

2
Q

What are the typical signs and symptoms of a neuroblastoma?

A

Majority of symptoms and signs occur either due to the mass effect of the tumour or as a result of metastases.

Symptoms:
Weight loss.
Fatigue. 
Anorexia.
Diahorrea.

Signs:
Hepatomegaly
Hypertension due to pressure on renal aa.

3
Q

What gene is associated with Neuroblastomas?

A

The Oncogene: MYCN

Amplification of the MYC protein is seen 25% cases and correlates with a poor prognosis.