Neurophysiology (scavma) Flashcards

1
Q

Neurons

A

Functional units of the nervous system

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Primary function of nervous system

A

To receive information form the environment and act on this information

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Signal information pathway through nervous system

A

Environment- sensory receptor- receptor (generator) potential- CNS- action potentials- output, muscle contraction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

CNS signal information

A

Action potential reaches CNS

then have synaptic transmission, post synaptic potentials, integration and action potentials which then leave

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Sensory transduction

A

Physical or chemical signal from environment is changed to an electrical signal known as receptor potential or generator potential which can lead to a potential

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Transient electrical signals

A

Generator potentials, Postsynaptic potentials also and action potentials

Convey info within and between the cells of the nervous system , all result in brief membrane changes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Membrane potential

A

Exchange of ions across the membrane is responsible for this potential and bioelectrical activity of the neuron

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Extracellular Na and Cl

A

Higher than intracellular and reverse for K, higher intracellular

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Electrical Potential

A

Difference between intracellular and extracellular fluid compartments

Intracellular is negative vs extracellular= membrane potential

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Depolarizing

A

Towards 0 and extracellular potential

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Hyperpolarization

A

More negative

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Resting potential

A

Resting, steady state

Excess of + along outside of membrane and - along inside

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

3 influential factors in ion movement

A

Concentration gradient, voltage gradient, membrane permeability

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Voltage gradients

A

For Na and K are inside because cell is negative

For Cl is outwards because attracted by outside +

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Net flux

A

Movement of ions across a membrane dependent on both the forces or gradients acting on that ion and permeability of the cell membrane to that ion

Flux= Pion x driving force

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Anions

A

Driving force is large but permeability is zero so no net flux

17
Q

At rest permeability

A

More permeable to K and Cl vs. Na

18
Q

Steady state transfer

A

3 Na in for every 2 K out

To offset passive movement cells like neurons have developed ATP dependent ion pumps which transport 3 Na out for every 2 in

So in steady state no net transfer

19
Q

Electrochemical potential gradient

A

Sum of 2 passive forces, concentration gradient of ion and voltage of electrical gradient

At rest this should be zero

20
Q

Potassium equilibrium potential

A

Membrane potential at which inward electrical flux is counterbalanced by outward diffusional flux

NERNST equation: Ek= RT/zF lnKo/Ki

At body temp: 61mVlog Ko/Ki

21
Q

Driving potential

A

Difference between the membrane potential and the Nernst potential for an ion is called this

Resting potential -equilibrium potential

22
Q

Change to relative permeability

A

When this changes for various ions this is the basis for electrical signals used by the nervous system for information processing

23
Q

Membrane potential in resting condition

A

Determined primarily by the K+ gradient

So that at body temp resting potential can be determined

If ratio of K and Na permeability changes this is what happens with electrical signal

24
Q

Na-K pump

A

In most excitable cells the active effluent of Na and active influx of K are coupled because move simultaneously

Phosphate bond of ATP provides energy

Mediated by enzyme which hydrolyzes ATP and activated by an increase in intracellular Na or extracellular K : Na, K activated ATPase

25
Q

Energy for transport

A

To transport Na and K against electrochemical gradients is 20% excess of energy capacity of neuron