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Flashcards in Nikoletta Lecs Deck (8)
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1
Q

What’s the purpose of dissolution testing?

A

As a quality control

Predict dosage form PK in vivo

2
Q

List 6 physiological conditions that can affect drug dissolution

A
Properties of GI fluids
Gastric emptying 
Intestinal transit time
GI motility & hydrodynamic patterns 
GI enzymes 
Fasted/fed state
3
Q

What does FaSSGF stand for?

A

Fasted state simulated gastric fluid

4
Q

What does FeSSIF stand for?

A

Fed state simulated intestinal fluid

5
Q

What does FaSSCoF stand for?

A

Fasted state simulated colonic fluid

6
Q

Name four types of dissolution apparatus

A

Rotating basket
Rotating paddle
Reciprocating cylinder bio-dis
Flow-through cell

7
Q

Name two closed system dissolution apparatuses

A

Basket

Paddle

8
Q

Define dissolution

A

The amount of active ingredient in a solid dosage form that is dissolved per unit time under standardised conditions of liquid solid interface, temperature and media composition