Non-Melanoma Skin Cancer

Question 0

characteristics of basal cell carcinoma

Answer 0

superificial 
nodular
morpheaform
infiltrative
punkus tumor

Question 1

wo types of non-melanoma skin cancer

Answer 1

proliferation of keratinocytes (SCC)

follicular related basal layer keratinocytes (BCC)

Question 2

squamous cell carcinoma

Answer 2

actinic keratosis

squamous cell carcinoma in situ aka bowen’s disease

Question 3

actinic keratosis

Answer 3

scaly rough red plaque due to damaged/atypical keratincoytes

superficial (not full thickness) epidermal atypical–>about 10% SCC

Question 4

characteristics of actinic keratosis

Answer 4

coarse and sand-paper like
better felt than tocuhed and can be very thich (horn-like)
can be tender too

Question 5

SCC in situ aka

Answer 5

bowen’s disease

Question 6

what does SCC ins itu look like

Answer 6

well defined pink/brown scaly plaques

full thickness epidermal keratinocytes

Question 7

SCC in situ–>SCC

Answer 7

26%

Question 8

SCC acounts for ___% of skin cancer

Answer 8

20

Question 9

SCC arise from

Answer 9

keratinocytes in epidermis

Question 10

mutation in SCC

Answer 10

TP53 in more than 90% of patients

Question 11

clinical presentation of SCC

Answer 11

red scaly plaque/nodule on sun exposed area
central scale or ulceration–typically older patients
often painful

Question 12

histology of SCC

Answer 12

atypical keratinocytes extend from the epidermis and invade into the dermis and sometimes beyond
keratin pearls
peri-neural invasion

Question 13

scc risk factors

Answer 13

UV
HPV
arsenic
immunosuppression
medications
light pigmentation
chronic inflammation
tobacco, alch

Question 14

keratoacanthoma

Answer 14

SCC subtype that tyically more indolent

usually grows fast than spontenously involutes; may be viral related

Question 15

tx of keratoacanthoma

Answer 15

MTX

Question 16

BCC is the most common

Answer 16

skin cancer and overall cancer

Question 17

sybtypes of BCC

Answer 17

nodular
superficial
micronodular
infiltrating
sclerosing/morpheaform

Question 18

nodular BCC

Answer 18

pearly papule/plaque that can ulcerate

*rarely mets

Question 19

superficial BCC

Answer 19

BCC budding from epidermis
sunexposed locations
harder to get off

Question 20

micronodular BCC

Answer 20

indistinguishable from nodular

Question 21

infiltrating BCC

Answer 21

head and neck of older adults

many clinical appearances

Question 22

sclerosing/morpheaform

Answer 22

scarlike without good reason

Question 23

side effects of liquid nitrogen

Answer 23

blistering–separation of epidermis and dermis–>white spots

Question 24

radiation pros

Answer 24

cosmetic, no cutting

Question 25

cons of radiation

Answer 25

many sessions, can be done only once and can stimulate tumors to become more aggressive