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Flashcards in nucleotide metabolism Deck (17)
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1
Q

amine donor for IMP–>XMP–>GMP

A

glutamine

2
Q

amine donor for IMP–>AMP

A

aspartate

3
Q

enyzme to create PRPP

A

PRPP synthetase

4
Q

redox cofacto for dehydroxylaing #2 carbon of ribose

A

Thioredoxin

5
Q

defect in adenosine deaminse

A

SCID

6
Q

defect in HGPRT

A

lesch nyan

7
Q

defect in purine nucleoside phosphorylase

A

CID

8
Q

which can be directly phospgoyrlated in purine salvage? Adenine, Guanine or Hypoxanthine?

A

Adenine

9
Q

self injusry , hyperuricemina, MR, dystonia, renal failure, sx of?

A

Lesch nyan

10
Q

low lymphocytes, skeletal abnormalites, sx of?

A

SCID

11
Q

neurologic symptoms, low T cell, FFF, chronic infection all sx of?

A

CID

12
Q

purine degradation lead to buildup of this in gout

A

uric acid

13
Q

treats gout by inhibiting xanthine oxidase

A

alloprinol

14
Q

needed for pyrimidine RNA synthesis

A

UTP and CTP

15
Q

needed for pyrmindine DNA synthesis

A

dCTP, DTTP

16
Q

needed for purine synthesis for RNA

A

GTP and ATP

17
Q

needed for purine synthesis for DNA

A

dGTP and dATP