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Flashcards in Other drugs Deck (4)
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1
Q

How does imetelstat work ?

A
  • Anti-sense therapy is when a genetic sequence is known to cause a particular disease, then a strand of DNA/RNA can be synthesised that will bind to mRNA produced by the genes and inactivate it.
  • Anti-sense oligonucleotides are small RNA/DNA molecules that are used for this purpose.
  • E.g.Imetelstat
  • Imetelstat is an antisense oligonucleotide that inhibits telomerase activity, and impede cell growth. It is in phase 2 trials for myeloproliferative neoplasms – myelofibrosis and ET
2
Q

How does sacubril work?

A
  • Sacubril is an neprilysin inhibitor
  • Neprilysin is responsible for degradation of ANP and BNP, which cause reduction in blood volume through decrease in systemic vascular resistance and increase in natriuresis, and thus decrease in afterload.
3
Q

What are the benefits of sacubril/valsartan?

A

• Reduction in CVD death, heart failure hospitalistaions, death from any cause by 20% compared to ACE alone

4
Q

How does riociguat work ?

A

In PAH there is dysfunction of the NO-soluble guanylate cyclase monophosphate pathway. Riocigiuat is an sGC stimulator causing vasodilation,